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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
Forward genetic screens in model organisms have provided important insights into numerous aspects of development, physiology and pathology. With the availability of complete genome sequences and theExpand
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RNA Chaperones, RNA Annealers and RNA Helicases
RNA molecules face difficulties when folding into their native structures. In the cell, proteins can assist RNAs in reaching their functionally active states by binding and stabilizing a specificExpand
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Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi
Genome-wide RNA interference (RNAi) screens have identified near-complete sets of genes involved in cellular processes. However, this methodology has not yet been used to study complex developmentalExpand
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The Recombinases DMC1 and RAD51 Are Functionally and Spatially Separated during Meiosis in Arabidopsis[W][OA]
This article presents evidence, obtained in Arabidopsis thaliana, that two central DNA repair proteins, the recombinases DMC1 and RAD51, are spatially and functionally separated, respectively, duringExpand
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The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity.
Genotoxic chemotherapy is the most common cancer treatment strategy. However, its untargeted generic DNA-damaging nature and associated systemic cytotoxicity greatly limit its therapeuticExpand
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Smc5/6-Mms21 Prevents and Eliminates Inappropriate Recombination Intermediates in Meiosis
Repairing broken chromosomes via joint molecule (JM) intermediates is hazardous and therefore strictly controlled in most organisms. Also in budding yeast meiosis, where production of enoughExpand
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Fractal video compression in OpenCL: An evaluation of CPUs, GPUs, and FPGAs as acceleration platforms
  • D. Chen, D. Singh
  • Computer Science
  • 18th Asia and South Pacific Design Automation…
  • 29 April 2013
We present a real-time implementation of a fractal compression algorithm that can be efficiently implemented in OpenCL and optimized for multi-CPUs, GPUs, and FPGAs. Expand
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Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line.
Near-haploid human cell lines are instrumental for genetic screens and genome engineering as gene inactivation is greatly facilitated by the absence of a second gene copy. However, no completelyExpand
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Transcription dynamically patterns the meiotic chromosome-axis interface
Meiotic chromosomes are highly compacted yet remain transcriptionally active. To understand how chromosome folding accommodates transcription, we investigated the assembly of the axial element, theExpand
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High-resolution, high-throughput SNP mapping in Drosophila melanogaster
Single nucleotide polymorphisms (SNPs) are useful markers for genetic mapping experiments in model organisms. Here we report the establishment of a high-density SNP map and high-throughput genotypingExpand
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