INBREEDING DEPRESSION AND ITS EVOLUTIONARY CONSEQUENCES
- D. Charlesworth, B. Charlesworth
- Biology
- 1987
The evidence that the evolution of breeding systems of animals and plants has been significantly influenced by the occurrence of inbreeding depression is reviewed, and the contemporary genetic theory of inmarriage depression and heterosis and the experimental data concerning the strength of in breeding depression are considered.
Rates of spontaneous mutation.
- J. Drake, B. Charlesworth, D. Charlesworth, J. Crow
- BiologyGenetics
- 1 April 1998
It is now possible to specify some of the evolutionary forces that shape these diverse mutation rates in broad groups of organisms.
The effect of deleterious mutations on neutral molecular variation.
- B. Charlesworth, M. Morgan, D. Charlesworth
- BiologyGenetics
- 1 August 1993
Observed reductions in molecular variation in low recombination genomic regions of sufficiently large size, for instance in the centromere-proximal regions of Drosophila autosomes or in highly selfing plant populations, may be partly due to background selection against deleterious mutations.
A Model for the Evolution of Dioecy and Gynodioecy
- B. Charlesworth, D. Charlesworth
- BiologyAmerican Naturalist
- 1 November 1978
The equilibria generated by the model agree closely with the results of genetical studies of those dioecious species with male-determining Y chromosomes that have been investigated, in which both male-and female-sterility factors have been found, showing complementary dominance relations and no crossing-over between the loci.
The genetics of inbreeding depression
- D. Charlesworth, J. Willis
- BiologyNature reviews genetics
- 1 November 2009
Inbreeding depression — the reduced survival and fertility of offspring of related individuals — occurs in wild animal and plant populations as well as in humans, indicating that genetic variation in…
Steps in the evolution of heteromorphic sex chromosomes
- D. Charlesworth, B. Charlesworth, G. Marais
- BiologyHeredity
- 1 August 2005
Evidence that recombination suppression occurs progressively in evolutionarily independent cases is reviewed, suggesting that selection drives loss of recombination over increasingly large regions.
Balancing Selection and Its Effects on Sequences in Nearby Genome Regions
- D. Charlesworth
- BiologyPLoS Genetics
- 1 April 2006
New sequence data being gathered from genes in which polymorphisms are known to be maintained by selection can be interpreted in conjunction with results from population genetics models that include recombination between selected sites and nearby neutral marker variants.
The effects of local selection, balanced polymorphism and background selection on equilibrium patterns of genetic diversity in subdivided populations.
- B. Charlesworth, M. Nordborg, D. Charlesworth
- BiologyGenetical research
- 1 October 1997
Levels of neutral genetic diversity in populations subdivided into two demes were studied by multilocus stochastic simulations, showing that, with population subdivision, local selection enhances between-deme diversity even at neutral sites distant from the polymorphic locus, producing higher FST values than with no selection.
Elements of Evolutionary Genetics
- B. Charlesworth, D. Charlesworth
- Biology
- 11 January 2010
The population dynamics of transposable elements
- B. Charlesworth, D. Charlesworth
- Biology
- 1 August 1983
Analytical and simulation models of the population dynamics of transposable elements in randomly mating populations, derived on the assumption of independence between different loci, and compared with simulation results show the general pattern seen in the simulations agrees quite well with theory.
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