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Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer.
G-quadruplexes are non-canonical DNA secondary structures putatively present in the promoter regions of oncogenes in the human genome. The targeting of promoter G-quadruplex structures to repressExpand
Molecular docking for virtual screening of natural product databases
Molecular docking enables the extraordinary structural diversity of natural products to be harnessed in an efficient manner. In this mini-review, we highlight recent examples of the use of molecularExpand
A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione.
A G-quadruplex-selective luminescent iridium(III) switch-on probe has been developed for the detection of cysteine (Cys) in aqueous solution. The system is highly sensitive and selective towards CysExpand
A Metal-Based Inhibitor of NEDD8-Activating Enzyme
A cyclometallated rhodium(III) complex [Rh(ppy)2(dppz)]+ (1) (where ppy = 2-phenylpyridine and dppz = dipyrido[3,2-a:2′,3′-c]phenazine dipyridophenazine) has been prepared and identified as anExpand
Bioactive iridium and rhodium complexes as therapeutic agents
Abstract Group 9 metal complexes based on iridium and rhodium have recently arisen as fascinating potential alternatives to existing platinum and ruthenium metallodrugs. While long regarded asExpand
G-quadruplexes for luminescent sensing and logic gates
G-quadruplexes represent a versatile sensing platform for the construction of label-free molecular detection assays owing to their diverse structures that can be selectively recognized byExpand
Drug repositioning by structure-based virtual screening.
This review article outlines the basic principles and recent advances in structure-based virtual screening and highlights the powerful synergy of in silico techniques in drug repositioning as demonstrated in several recent reports. Expand
Simple and convenient G-quadruplex-based turn-on fluorescence assay for 3' → 5' exonuclease activity.
A selective, oligonucleotide-based, label-free, turn-on fluorescence detection method for 3' → 5' exonuclease activity has been developed using crystal violet as a G-quadruplex-binding probe. TheExpand
Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe.
A label-free, oligonucleotide-based, switch-on luminescence detection method for T4 polynucleotide kinase activity has been developed using a novel G-quadruplex-selective luminescent Ir(iii) complexExpand
Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening
STAT3 regulates a variety of genes involved with cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, inflammation, and immunity. The purpose of this study was to apply molecularExpand