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Occurrence and relevance of filamentous fungi in respiratory secretions of patients with cystic fibrosis--a review.
TLDR
In CF patients, fungi may sometimes be responsible for deterioration of lung function, as occurs in allergic broncho-pulmonary aspergillosis (ABPA), which is the most common fungal disease in this context. Expand
Mechanisms of Azole Resistance in Petite Mutants of Candida glabrata
TLDR
Resistance or decreased susceptibility to azoles in petite mutants of C. glabrata is associated with increased expression of CgCDR1 and, to a lesser extent, of C gCDR2, which would explain their increased susceptibility to polyenes. Expand
Sialic acid-dependent recognition of laminin and fibrinogen by Aspergillus fumigatus conidia
TLDR
The results strengthen the idea that the laminin and fibrinogen receptors in A. fumigatus are identical and suggest an interaction mediated by a sialic acid-specific lectin of the conidial wall. Expand
Mechanisms of Azole Resistance in a Clinical Isolate of Candida tropicalis
TLDR
Overexpression of CtERG11 associated with a missense mutation in this gene seemed to be responsible for the acquired azole resistance of this clinical isolate of Candida tropicalis. Expand
Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia
TLDR
Melanin is suggested to have an indirect role in virulence, because it is required for correct assembly of the cell wall layers of the conidia of A. fumigatus and the expression at the conidial surface of adhesins and other virulence factors. Expand
Relationships between Respiration and Susceptibility to Azole Antifungals in Candida glabrata
TLDR
Blockage of respiration in C. glabrata induces decreased susceptibility to azoles, culminating in azole resistance due to the deletion of mtDNA, which could explain the induction of petite mutations by azole antifungals which have been demonstrated to act directly on the mitochondrial respiratory chain. Expand
In-vivo selection of an azole-resistant petite mutant of Candida glabrata.
TLDR
Evidence is provided that the selection of azole-resistant petite mutants of C. glabrata may occur in vivo after fluconazole administration, which might explain, therefore, clinical failure of antifungal therapy. Expand
Clinical Significance of Scedosporium apiospermum in Patients with Cystic Fibrosis
TLDR
The results clearly demonstrate that the frequency of this fungus is largely underestimated and that it may trigger an inflammatory response, thus suggesting a pathogenic role in patients with cystic fibrosis. Expand
Reduced Susceptibility to Polyenes Associated with a Missense Mutation in the ERG6 Gene in a Clinical Isolate of Candida glabrata with Pseudohyphal Growth
TLDR
It is demonstrated that mutation in the CgERG6 gene may lead to a reduced susceptibility to polyenes and to a pseudohyphal growth due to the subsequent changes in sterol content of the plasma membrane. Expand
In-vitro resistance to azoles associated with mitochondrial DNA deficiency in Candida glabrata.
TLDR
The relationship between mtDNA deficiency and resistance to azoles is demonstrated, and this model provides an interesting model to study the mechanisms of action of these antifungal agents. Expand
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