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Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.
Multilocus sequence typing (MLST), which exploits the unambiguous nature and electronic portability of nucleotide sequence data for the characterization of microorganisms, can be applied to almost all bacterial species and other haploid organisms, including those that are difficult to cultivate. Expand
Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics
Methodes d'extraction d'enzymes, d'electrophorese en gel et de coloration specifique des enzymes utilisees pour etudier la variation genetique chez Escherichia coli et d'autres bacteries. LesExpand
Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis—One Species on the Basis of Genetic Evidence
It is shown by multilocus enzyme electrophoresis and by sequence analysis of nine chromosomal genes that B. anthracis should be considered a lineage of B. cereus and this determination is not only a formal matter of taxonomy but may also have consequences with respect to virulence and the potential of horizontal gene transfer within the B. Cereus group. Expand
Population genetics and molecular epidemiology of Neisseria meningitidis
  • D. Caugant
  • Biology, Medicine
  • APMIS : acta pathologica, microbiologica, et…
  • 1 January 1998
The characteristics of the predominant clones which are nowadays causing meningococcal disease in the world are summarized here and the importance of population genetics in interpreting the epidemiological data is illustrated. Expand
Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment.
MATS analysis showed that a multicomponent vaccine could protect against a substantial proportion of invasive MenB strains isolated in Europe, however, monitoring of antigen expression will be needed in the future. Expand
Meningococcal carriage and disease—Population biology and evolution
The application of insights gained from studies of meningococcal population biology and evolution is important in understanding the spread of disease, as well as in vaccine development and implementation, especially with regard to the challenge of producing comprehensive vaccines based on sub-capsular antigens and measuring their effectiveness. Expand
Taxonomic relationships of the [Pasteurella] haemolytica complex as evaluated by DNA-DNA hybridizations and 16S rRNA sequencing with proposal of Mannheimia haemolytica gen. nov., comb. nov.,
Based on the polyphasic investigation performed a new genus Mannheimia is proposed for the trehalose-negative [P.] haemolytica complex, and two previously named species are transferred to this new genus and three new species are described. Expand
Multilocus Sequence Typing Scheme for Bacteria of the Bacillus cereus Group
The MLST scheme which was developed has a high level of resolution and should be an excellent tool for studying the population structure and epidemiology of the B. cereus group. Expand
Intercontinental spread of a genetically distinctive complex of clones of Neisseria meningitidis causing epidemic disease.
Strains of Neisseria meningitidis responsible for an epidemic of meningococcal disease occurring in Norway since the mid-1970s and for recent increases in the incidence of disease in several otherExpand
NadA, a Novel Vaccine Candidate of Neisseria meningitidis
NadA has a predicted molecular structure strikingly similar to a novel class of adhesins, forms high molecular weight oligomers, and binds to epithelial cells in vitro supporting the hypothesis that NadA is important for host cell interaction, and may represent a novel antigen for a vaccine able to control meningococcal disease caused by three hypervirulent lineages. Expand