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Core outcome measures for chronic pain clinical trials: IMMPACT recommendations
Recommendations for the core outcome domains that should be considered by investigators conducting clinical trials of the efficacy and effectiveness of treatments for chronic pain are provided. Expand
Pain Management: A Fundamental Human Right
It is concluded that pain management is at an “inflection point” in which unreasonable failure to treat pain is viewed worldwide as poor medicine, unethical practice, and an abrogation of a fundamental human right. Expand
American pain society recommendations for improving the quality of acute and cancer pain management: American Pain Society Quality of Care Task Force.
Efforts to improve the quality of pain management must move beyond assessment and communication of pain to implementation and evaluation of improvements in pain treatment that are timely, safe, evidence based, and multimodal. Expand
Core outcome domains for chronic pain clinical trials: IMMPACT recommendations
Development of a core set of outcome domains would facilitate comparison and pooling of data, encourage more complete reporting of outcomes, simplify the preparation and review of research proposals and manuscripts, and allow clinicians to make informed decisions regarding the risks and benefits of treatment. Expand
Neurolytic Celiac Plexus Block for Treatment of Cancer Pain: A Meta-Analysis
A meta-analysis of the efficacy and safety of neurolytic celiac plexus block (NCPB) for cancer pain suggests that NCPB has long-lasting benefit for 70%-90% of patients with pancreatic and other intraabdominal cancers, regardless of the technique used. Expand
The Comparative Effects of Postoperative Analgesic Therapies on Pulmonary Outcome: Cumulative Meta-Analyses of Randomized, Controlled Trials
Meta-analyses of randomized, control trials confirm that postoperative epidural pain control can significantly decrease the incidence of pulmonary morbidity and support the utility of epidural analgesia for reducing postoperativemonary morbidity but do not support the use of surrogate measures of pulmonary outcome as predictors or determinants of pulmonary mortality in postoperative patients. Expand
Itching after epidural and spinal opiates
A hypothesis to explain spinal opiate‐induced itching is stated and the possible mechanisms of the effect are explored and benefit may be derived from better understanding the phenomenon. Expand
Patient controlled opioid analgesia versus conventional opioid analgesia for postoperative pain.
- J. Hudcová, E. McNicol, C. Quah, J. Lau, D. Carr
- The Cochrane database of systematic reviews
- 18 October 2006
PCA provided better pain control and greater patient satisfaction than conventional parenteral 'as-needed' analgesia and was an efficacious alternative to conventional systemic analgesia for postoperative pain control. Expand
Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review.
- E. McNicol, N. Horowicz-Mehler, +5 authors D. Carr
- The journal of pain : official journal of the…
- 1 June 2003
Well-designed trials in the specified populations are required to furnish clinicians with secure evidence on managing opioid side effects successfully, and the lack of well-designed, randomized controlled trials and the heterogeneity of populations and study designs made the drawing of firm conclusions difficult and precluded performance of meta-analysis. Expand
Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials.
Short-term studies provide only equivocal evidence regarding the efficacy of opioids in reducing the intensity of neuropathic pain, and further RCTs are needed to establish their long-term efficacy, safety, and effects on quality of life. Expand