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Efficacy of mirtazapine in obstructive sleep apnea syndrome.
STUDY OBJECTIVES Decreased serotonergic facilitation of upper-airway motor neurons during sleep has been postulated as an important mechanism rendering the upper airway vulnerable to obstruction inExpand
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Aging of modulation of heart rate.
We postulated that measurements of autonomically mediated fluctuations in heart rate might provide a quantitative probe of biological aging. We used power spectrum analysis of instantaneous heartExpand
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Upper airway and respiratory muscle responses to continuous negative airway pressure.
To determine upper airway and respiratory muscle responses to nasal continuous negative airway pressure (CNAP), we quantitated the changes in diaphragmatic and genioglossal electromyographicExpand
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A minimal mathematical model of human periodic breathing.
Numerous mathematical models of periodic breathing (PB) currently exist. These models suggest mechanisms that may underlie many known causes of PB. However, each model that has been shown to simulateExpand
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Respiratory and arousal responses to acoustic stimulation.
STUDY OBJECTIVES Although sleep-related obstructive apnea is most often associated with transient arousal, the impact of this arousal on respiratory control remains unclear. We tested the hypothesesExpand
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Innovative treatments for adults with obstructive sleep apnea
Obstructive sleep apnea (OSA) affects one in five adult males and is associated with significant comorbidity, cognitive impairment, excessive daytime sleepiness, and reduced quality of life. For overExpand
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Diazepam suppresses sleep apneas in rats.
To test the respiratory effects of benzodiazepines in an established animal model of central apnea, we administered nonhypnotic and hypnotic doses of diazepam to nine adult male Sprague-Dawley ratsExpand
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Respiratory pattern modulation by the pedunculopontine tegmental nucleus
This study demonstrates respiratory modulation caused by stimulation of the pedunculopontine tegmental nucleus (PPT), a structure not classically included in the pontine respiratory neuronal network.Expand
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