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Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways
Melatonin, an endogenous signal of darkness, is an important component of the body's internal time-keeping system. As such it regulates major physiological processes including the sleep wake cycle,Expand
Melatonin: Nature's most versatile biological signal?
Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans,Expand
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors
The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the concentration ofExpand
Melatonin—A pleiotropic, orchestrating regulator molecule
Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous systemExpand
Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes
The pineal product melatonin has remarkable antioxidant properties. It is secreted during darkness and plays a key role in various physiological responses including regulation of circadian rhythms,Expand
Potential use of melatonergic drugs in analgesia: Mechanisms of action
Melatonin is a remarkable molecule with diverse physiological functions. Some of its effects are mediated by receptors while other, like cytoprotection, seem to depend on direct and indirectExpand
Therapeutic Actions of Melatonin in Cancer: Possible Mechanisms
Melatonin is a phylogenetically well-preserved molecule with diverse physiological functions. In addition to its well-known regulatory control of the sleep/wake cycle, as well as circadian rhythmsExpand
Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders
The circadian rhythm of melatonin in saliva or plasma, or of the melatonin metabolite 6-sulphatoxymelatonin (aMT6S) in urine, is a defining feature of suprachiasmatic nucleus (SCN) function, theExpand
Pathophysiology of depression: Role of sleep and the melatonergic system
Profound disturbances in sleep architecture occur in major depressive disorders (MDD) and in bipolar affective disorders. Reduction in slow wave sleep, decreased latency of rapid eye movement (REM)Expand
Melatonin effects on bone: experimental facts and clinical perspectives
Abstract: Bone formation proceeds through a remodeling process that runs continuously, involving the resorption of old bone by osteoclasts, and the subsequent formation of new bone by osteoblasts.Expand