• Publications
  • Influence
External Lipid PI3P Mediates Entry of Eukaryotic Pathogen Effectors into Plant and Animal Host Cells
TLDR
It is shown that effectors of another pathogen type, fungi, contain functional variants of the RXLR motif, and that the oomycete and fungal RX LR motifs enable binding to the phospholipid, phosphatidylinositol-3-phosphate (PI3P). Expand
External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells.
TLDR
It is shown that effectors of another pathogen type, fungi, contain functional variants of the RXLR motif, and that the oomycete and fungal RX LR motifs enable binding to the phospholipid, phosphatidylinositol-3-phosphate (PI3P). Expand
The DIX domain targets dishevelled to actin stress fibres and vesicular membranes
TLDR
It is proposed that partitioning of Dvl into cytoskeletal and vesicular pools by the DIX domain represents a point of divergence in Wnt signalling. Expand
Structural basis for interactions of the Phytophthora sojae RxLR effector Avh5 with phosphatidylinositol 3-phosphate and for host cell entry.
TLDR
This work structurally and functionally characterized the P. sojae effector, avirulence homolog-5 (Avh5), and proposes a model where Avh5 interacts with PtdIns(3)P through its C terminus, and by binding of the RFLR motif, which promotes host cell entry. Expand
Tollip: a multitasking protein in innate immunity and protein trafficking.
  • D. Capelluto
  • Biology, Medicine
  • Microbes and infection
  • 1 February 2012
TLDR
The multitasking role of Tollip associated with its modular architecture is discussed, which is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. Expand
A Novel Heme-Regulatory Motif Mediates Heme-Dependent Degradation of the Circadian Factor Period 2
TLDR
The data support a model where heme-mediated oxidation triggers hPer2 degradation, thus controlling heterodimerization and ultimately gene transcription. Expand
Molecular Mechanisms Responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide
TLDR
Subclinical low-dose LPS skews macrophages into a mild proinflammatory state, through cell surface TLR4, IL-1R–associated kinase-1, and the Toll-interacting protein, allowing mild induction of proinflammatory mediators. Expand
Multivalent Mechanism of Membrane Insertion by the FYVE Domain*
TLDR
The FYVE domain is targeted to endosomes through the synergistic action of stereospecific PtdIns(3)P head group ligation, hydrophobic insertion and electrostatic interactions with acidic phospholipids. Expand
Sulfatides Partition Disabled-2 in Response to Platelet Activation
TLDR
The experimental data support a model where two pools of Dab2 co-exist at the platelet surface, in both sulfatide- and integrin receptor-bound states, and their balance controls the extent of the clotting response. Expand
Disabled‐2: A modular scaffold protein with multifaceted functions in signaling
TLDR
The most recent and comprehensive analysis of Dab2's action as a mediator of homotypical and heterotypical interactions is provided and highlights the various novel mechanisms by which the protein mediates an array of signaling events with vast physiological consequences. Expand
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