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Transglutaminase inhibition by 2-[(2-oxopropyl)thio]imidazolium derivatives: mechanism of factor XIIIa inactivation.
The physiologic role of several transglutaminases could be more precisely defined with the development of specific inhibitors for these enzymes with therapeutic utility in the treatment of thrombosis and the observed enhancements in clot lysis rates were studied. Expand
Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by…
Cardiac electrophysiologic and antiarrhythmic actions of tedisamil.
- A. Wallace, R. Stupienski, +6 authors J. Lynch
- The Journal of pharmacology and experimental…
- 1 April 1995
The latter findings suggest that tedisamil might be useful in the prevention of malignant ventricular arrhythmias in the setting of myocardial ischemic injury. Expand
Facile intramolecular tosylhydrazone-mediated cyclopropanation reactions of 4-(2-formylphenyl)-1,4-dihydropyridines
SYNTHESES OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE.
Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists.
- N. Liverton, D. J. Armstrong, +5 authors R. Gould
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 3 March 1998
The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinzolinones demonstrates the utility of these structures as central templates for nonpeptide RGD mimics. Expand
Steroid Homologs Containing Pyridazinone and Related Nuclei1
Syntheses of 5-Trifluoromethyluracil and 5-Trifluoromethyl-2″-Deoxyuridine
Inhibition of factor XIIIa in a canine model of coronary thrombosis: effect on reperfusion and acute reocclusion after recombinant tissue-type plasminogen activator.
It is demonstrated that pretreatment with L-722,151 hastens reperfusion time threefold and reduces residual thrombus mass, which may determine resistance to plasmin-mediated fibrin degradation, occur rapidly. Expand