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Transglutaminase inhibition by 2-[(2-oxopropyl)thio]imidazolium derivatives: mechanism of factor XIIIa inactivation.
TLDR
The physiologic role of several transglutaminases could be more precisely defined with the development of specific inhibitors for these enzymes with therapeutic utility in the treatment of thrombosis and the observed enhancements in clot lysis rates were studied. Expand
Cardiac electrophysiologic and antiarrhythmic actions of tedisamil.
TLDR
The latter findings suggest that tedisamil might be useful in the prevention of malignant ventricular arrhythmias in the setting of myocardial ischemic injury. Expand
Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists.
TLDR
The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinzolinones demonstrates the utility of these structures as central templates for nonpeptide RGD mimics. Expand
Inhibition of factor XIIIa in a canine model of coronary thrombosis: effect on reperfusion and acute reocclusion after recombinant tissue-type plasminogen activator.
TLDR
It is demonstrated that pretreatment with L-722,151 hastens reperfusion time threefold and reduces residual thrombus mass, which may determine resistance to plasmin-mediated fibrin degradation, occur rapidly. Expand
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