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Mollamides B and C, Cyclic Hexapeptides from the Indonesian Tunicate Didemnum molle
Two new cyclic hexapeptides, mollamides B and C, were isolated from the Indonesian tunicate Didemnum molle along with the known peptide keenamide A and mollamide B and show cytotoxicity against several cancer cell lines. Expand
Batzelladine alkaloids from the caribbean sponge Monanchora unguifera and the significant activities against HIV-1 and AIDS opportunistic infectious pathogens
Abstract Five new polycyclic guanidine alkaloids, 16β-hydroxycrambescidin 359 (1), batzelladines K, L, M, and N (2–5), along with the previously reported ptilomycalin A (6), crambescidine 800 (7),Expand
Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.
Compounds 1, 4, and 5 demonstrated in vitro antimalarial activity against Plasmodium falciparum (W-2 clone), while 2 was inactive and 2 showed in vitro cytotoxicity to selected human cancer cell lines (IC50 = 3-6 microg/mL against SK-MEL, KB, BT-549, and SK-OV-3), and 4 was also cytotoxic to human malignant melanoma. Expand
New alkamides from maca (Lepidium meyenii).
Five new alkamides have been found from only L. meyenii and could be used as markers for authentication and standardization and the identity of N-benzyl-15Z-tetracosenamide was confirmed by synthesis. Expand
Kahalalides: Bioactive Peptides from a Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp.(1).
Six new peptides are described, including kahalalide F, which are cyclic depsipeptides, ranging from a C(31) tripeptide to aC(75) tridecapeptide isolated from a sacoglossan mollusk, Elysiarufescens. Expand
Antiparasitic alkaloids from Psychotria klugii.
Alkaloids 1 and 3 exhibited potent antimalarial activity against Plasmodium falciparum clones W2 and D6 and Compound 3 was cytotoxic to SK-MEL, KB, BT-549, and SK-OV-3 human cancer cells, while 1 was inactive. Expand
New constituents from noni (Morinda citrifolia) fruit juice.
Morinda citrifolia L. (Rubiaceae), known as noni, has a long history of traditional use in the Hawaiian and Tahitian islands. More recently, an array of commercial noni fruit juice products areExpand
Araguspongines K and L, new bioactive bis-1-oxaquinolizidine N-oxide alkaloids from Red Sea specimens of Xestospongia exigua.
Two new N-oxide araguspongines, (+)-araguspongine K and (+-arag Suspongine L, are described here, established on the basis of spectral analyses including (1)H-(15)N HMBC. Expand
Antimicrobial and antiparasitic (+)-trans-hexahydrodibenzopyrans and analogues from Machaerium multiflorum.
Machaerium multiflorum yielded two additional new (+)-trans-hexahydrodibenzopyrans (HHDBP's), machaeriol C (1) and machaeriol D (2), and three new 5,6-seco-HHDBP's, machaeridiol A (3), machaeridiol BExpand