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Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases
One general principle of gene regulation is that DNA-binding transcription factors modulate transcription by recruiting cofactors that modify histones and chromatin structure. A second implicitExpand
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Cell Cycle and Biochemical Effects of PD 0183812
Progression through the G1 phase of the cell cycle requires phosphorylation of the retinoblastoma gene product (pRb) by the cyclin D-dependent kinases CDK4 and CDK6, whose activity can specificallyExpand
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Is histone acetylation the most important physiological function for CBP and p300?
Protein lysine acetyltransferases (HATs or PATs) acetylate histones and other proteins, and are principally modeled as transcriptional coactivators. CREB binding protein (CBP, CREBBP) and its paralogExpand
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Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.
Opposing activities of acetyltransferases and deacetylases help regulate energy balance. Mice heterozygous for the acetyltransferase CREB binding protein (CBP) are lean and insulin sensitized, butExpand
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Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice
Autism spectrum disorders (ASDs) are a group of neurodevelopmental afflictions characterized by repetitive behaviors, deficits in social interaction, and impaired communication skills. For most ASDExpand
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S6K1: reducing the RiSKs of aging
  • D. C. Bedford
  • Biology, Medicine
  • Disease Models & Mechanisms
  • 1 March 2010
Caloric restriction (CR) can protect against aging and disease in a number of model systems, including primates ([Colman et al., 2009][1]). However, the underlying mechanisms by which CR affectsExpand
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