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Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test.
An in vitro method of detecting synergy which is simple to perform, accurate, and reproducible and has the potential for clinical extrapolation is desirable. Time-kill and checkerboard methods areExpand
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Polymyxins and Doripenem Combination Against KPC-Producing Klebsiella pneumoniae
Background Most KPC-producing organisms have maintained susceptibility to polymyxins; however, development of resistance to polymyxins has been increasingly reported. One potential treatment modalityExpand
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Enrichment with anti-cytokeratin alone or combined with anti-EpCAM antibodies significantly increases the sensitivity for circulating tumor cell detection in metastatic breast cancer patients
IntroductionCirculating tumor cells (CTCs) are detectable in most cancer patients and they can meet an existing medical need to monitor cancer patients during a course of treatment and to helpExpand
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Pharmacokinetics and pharmacodynamics of cefepime administered by intermittent and continuous infusion.
OBJECTIVE This study assessed the pharmacokinetics and pharmacodynamics of cefepime administered by intermittent and continuous infusion against clinical isolates of Pseudomonas aeruginosa,Expand
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Effectiveness of Statins in Reducing the Rate of Severe Sepsis: A Retrospective Evaluation
Study Objectives. To determine whether use of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors (statins) is associated with a reduced rate of severe sepsis, and to further characterize theExpand
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Use of pharmacokinetics and pharmacodynamics to optimize antimicrobial treatment of Pseudomonas aeruginosa infections.
  • D. Burgess
  • Medicine
  • Clinical infectious diseases : an official…
  • 15 February 2005
The study of pharmacodynamics has greatly enhanced our understanding of antimicrobials and has enabled us to optimize dosing regimens. Applying this knowledge to the clinical setting can be criticalExpand
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Extended‐Spectrum β‐Lactamases: Epidemiology, Detection, and Treatment
Extended‐spectrum β‐lactamases (ESBLs) are extremely broad spectrum β‐lactamase enzymes found in a variety of Enterobacteriaceae. Most strains producing these β‐lactamases are Klebsiella pneumoniae,Expand
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Guideline-concordant antibiotic use and survival among patients with community-acquired pneumonia admitted to the intensive care unit.
OBJECTIVE This study evaluated the survival benefit of US community-acquired pneumonia (CAP) practice guidelines in the intensive care unit (ICU) setting. METHODS We conducted a retrospectiveExpand
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Increases in SLT2 Expression and Chitin Content Are Associated with Incomplete Killing of Candida glabrata by Caspofungin
ABSTRACT Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activityExpand
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Effect of fluvastatin and pravastatin, HMG-CoA reductase inhibitors, on fluconazole activity against Candida albicans.
Synergy between fluvastatin, at clinically unachievable concentrations, and fluconazole against Candida albicans has been reported. The purpose of the present study was to evaluate the in-vitroExpand
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