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Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.
A first series of high-affinity, selective CYP2J2 inhibitors that are related to terfenadine, with K(i) values as low as 160nM, are reported, that should be useful tools to determine the biological roles of CYP 2J2. Expand
The microbial reduction of 2-chloro-3-oxoesters
Abstract Several aliphatic or aromatic 2-chloro-3-oxoesters are stereoselectively reduced by yeast or fungal strains, affording in fair to good yield and high enantiomeric excess some of theExpand
Bioelectro-Fenton: A sustainable integrated process for removal of organic pollutants from water: Application to mineralization of metoprolol.
A hybrid process coupling electro-Fenton process and aerobic biological treatment was implemented for the efficient and cost-effective mineralization of beta-blocker metoprolol (MPTL) aqueous solutions, demonstrating its potentiality for treating wastewater containing pharmaceutical residues. Expand
One-step enantioselective synthesis of (4S)-isosclerone through biotranformation of juglone by an endophytic fungus
Abstract We describe here a direct access to (4S)-isosclerone (+)-1, an important structural component of several natural products featuring a spirobisnaphthalene ring system. Starting with theExpand
The fungal leaf endophyte Paraconiothyrium variabile specifically metabolizes the host-plant metabolome for its own benefit.
Out of more than a thousand molecules present in the crude extract of the plant leaf, a specific biotransformation of glycosylated flavonoids by the endophyte led to the production of the corresponding aglycone via deglycosylation, illustrating the chemical cooperation underlying the mutualistic relationship between the plant and the startophyte. Expand
A study of the stereocontrolled reduction of aliphatic β-ketoesters by Geotrichum candidum
The conditions necessary to reduce stereoselectively aliphatic beta-ketoesters by G. candidum have been investigated. Ageing of the mycelium allowed a practical preparation of optically pureExpand
A new cytochrome P450 belonging to the 107L subfamily is responsible for the efficient hydroxylation of the drug terfenadine by Streptomyces platensis.
Results confirmed that P450s from Streptomyces species are interesting tools for the biotechnological production of secondary metabolites, such as antibiotics or antitumor compounds, and in the oxidative biotransformation of xenobiotics,such as drugs. Expand
Molecular crosstalk between the endophyte Paraconiothyrium variabile and the phytopathogen Fusarium oxysporum - modulation of lipoxygenase activity and beauvericin production during the interaction.
The mechanisms underlying changes in the chemical communication and physiological interactions between the fungal endophyte Paraconiothyrium variabile and the phytopathogen Fusarium oxysporum are addressed, including the interaction between the protagonists in planta. Expand
Electrochemical advanced oxidation for cold incineration of the pharmaceutical ranitidine: mineralization pathway and toxicity evolution.
Overall results confirm the effectiveness of EAOPs for the efficient removal of RNTD and its oxidation by-products from water. Expand