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Diagnosis and treatment of inherited factor X deficiency
Patients with moderate–severe FX deficiency may have symptoms similar to that of haemophilia A and B, including haemarthrosis, intracranial haemorrhage, and gastrointestinal bleeding, andotype characterization may offer important clues about clinical prognosis. Expand
Dose Responses for Adaption to Low Doses of 60Co γ Rays and 3H β Particles in Normal Human Fibroblasts
It is demonstrated that doses as low as (on average) about one track per cell (1 mGy) produce the same maximum adaptive response as do doses that deposit many tracks per cell, and that the two radiations were not different in this regard. Expand
Changes in distribution of nuclear matrix antigens during the mitotic cell cycle
- N. Chaly, T. Bladon, G. Setterfield, J. Little, J. Kaplan, D. Brown
- Medicine, Biology
- The Journal of cell biology
- 1 August 1984
The distribution of nonlamin nuclear matrix antigens during the mitotic cell cycle in mouse 3T3 fibroblasts was examined to suggest that the antigen may play a role in maintaining interphase and mitotic chromosome order. Expand
Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene.
The view that naphthalene-induced pulmonary damage is mediated by the cytochrome P-450-dependent metabolism of naphhalene and that glutathione plays an important role in the detoxification of the lung damaging metabolite(s) is supported. Expand
Dose responses for adaption to low doses of (60)Co gamma rays and (3)H beta particles in normal human fibroblasts.
It is demonstrated that doses as low as about one track per cell (1 mGy) produce the same maximum adaptive response as do doses that deposit many tracks per cell, and that the two radiations were not different in this regard. Expand
Apoptosis and the adaptive response in human lymphocytes.
The results show that Go lymphocytes pre-exposed to an adapting dose of radiation or DNA strand breaking agent are not protected but can become sensitized to subsequent apoptosis induced by radiation (a kinetically slow process), while cellular sensitization for apoptosis may represent a novel adaptive response mechanism. Expand
Two pathways for the induction of apoptosis in human lymphocytes.
- S. Cregan, B. P. Smith, D. Brown, R. Mitchel
- Biology, Medicine
- International journal of radiation biology
Slow repaired or unrepairable DNA lesions, such as some of those produced by ionizing radiation exposure, trigger apoptosis by a kinetically slow process, distinct from a fast process not induced by radiation but which is induced by membrane-oxidizing agents. Expand
Expression and posttranslational modification of class III beta-tubulin during neuronal differentiation of P19 embryonal carcinoma cells.
The results implicate posttranslational modifications of beta-III tubulin in the increased microtubule stability noted in differentiating P19 neurons. Expand
Serum antibodies to oxidized low-density lipoprotein and ceroid in chronic periaortitis.
- D. Parums, D. Brown, M. J. Mitchinson
- Archives of pathology & laboratory medicine
- 1 April 1990
Findings show that chronic periaortitis is accompanied by autoallergy to ceroid, which is probably at least partly composed of low-density lipoprotein oxidized within the human atherosclerotic plaque, and that a number of middle-aged and elderly people without chronic perIAortitis also have such antibodies. Expand
Differential sorting of beta tubulin isotypes into colchicine-stable microtubules during neuronal and muscle differentiation of embryonal carcinoma cells.
Comparisons of class I, II, III, and IV beta tubulin isotypes in total and colchicine-stable microtubule (MT) arrays from uncommitted EC, neuronal, and muscle cells were made by immunoblotting and by indirect immunofluorescence microscopy. Expand