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Dose Responses for Adaption to Low Doses of 60Co γ Rays and 3H β Particles in Normal Human Fibroblasts
It is demonstrated that doses as low as (on average) about one track per cell (1 mGy) produce the same maximum adaptive response as do doses that deposit many tracks per cell, and that the two radiations were not different in this regard.
Changes in distribution of nuclear matrix antigens during the mitotic cell cycle
- N. Chaly, T. Bladon, G. Setterfield, J. Little, J. Kaplan, D. Brown
- BiologyThe Journal of cell biology
- 1 August 1984
The distribution of nonlamin nuclear matrix antigens during the mitotic cell cycle in mouse 3T3 fibroblasts was examined to suggest that the antigen may play a role in maintaining interphase and mitotic chromosome order.
Serum antibodies to oxidized low-density lipoprotein and ceroid in chronic periaortitis.
- D. Parums, D. Brown, M. J. Mitchinson
- Medicine, BiologyArchives of pathology & laboratory medicine
- 1 April 1990
Findings show that chronic periaortitis is accompanied by autoallergy to ceroid, which is probably at least partly composed of low-density lipoprotein oxidized within the human atherosclerotic plaque, and that a number of middle-aged and elderly people without chronic perIAortitis also have such antibodies.
Evidence for cytochrome P-450 mediated metabolism in the bronchiolar damage by naphthalene.
Dose responses for adaption to low doses of (60)Co gamma rays and (3)H beta particles in normal human fibroblasts.
It is demonstrated that doses as low as about one track per cell (1 mGy) produce the same maximum adaptive response as do doses that deposit many tracks per cell, and that the two radiations were not different in this regard.
Apoptosis and the adaptive response in human lymphocytes.
The results show that Go lymphocytes pre-exposed to an adapting dose of radiation or DNA strand breaking agent are not protected but can become sensitized to subsequent apoptosis induced by radiation (a kinetically slow process), while cellular sensitization for apoptosis may represent a novel adaptive response mechanism.
Apoptosis down-regulates inflammation under the advancing epithelial wound edge: delayed patterns in diabetes and improvement with topical growth factors.
Two pathways for the induction of apoptosis in human lymphocytes.
- S. Cregan, B. P. Smith, D. Brown, R. Mitchel
- Biology, ChemistryInternational journal of radiation biology
Slow repaired or unrepairable DNA lesions, such as some of those produced by ionizing radiation exposure, trigger apoptosis by a kinetically slow process, distinct from a fast process not induced by radiation but which is induced by membrane-oxidizing agents.
Differential sorting of beta tubulin isotypes into colchicine-stable microtubules during neuronal and muscle differentiation of embryonal carcinoma cells.
Comparisons of class I, II, III, and IV beta tubulin isotypes in total and colchicine-stable microtubule (MT) arrays from uncommitted EC, neuronal, and muscle cells were made by immunoblotting and by indirect immunofluorescence microscopy.
Tubulin synthesis and assembly in differentiating neurons.
It is concluded that the developmental regulation of microtubules in neurons may require the coordinated expression and posttranslational modifications of tubulin and microtubule-associated proteins to provide biochemical forms that favour specific interactions.