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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
TLDR
A comprehensive longitudinal review of AstraZeneca's small-molecule drug projects from 2005 to 2010 allowed us to establish a framework based on the five most important technical determinants of project success and pipeline quality, which are described as the five 'R's'.
Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.
TLDR
A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.
Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules.
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