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Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain
TLDR
A crucial and unexpected role for Sox2 in the maintenance of neurones in selected brain areas is highlighted, and a contribution of neural cell proliferative defects to the pathological phenotype is suggested.
Chronic Δ9-Tetrahydrocannabinol During Adolescence Provokes Sex-Dependent Changes in the Emotional Profile in Adult Rats: Behavioral and Biochemical Correlates
TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.
Potential anxiolytic‐ and antidepressant‐like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents
TLDR
The possible anxiolytic‐ and antidepressant‐like effects of the κ‐opioid receptor agonist salvinorin A, the main active ingredient of Salvia divinorum, in rats and mice are investigated.
Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood
TLDR
The data suggest that THC pretreated rats may establish less synaptic contacts and/or less efficient synaptic connections throughout the hippocampus and this could represent the molecular underpinning of the cognitive deficit induced by adolescent THC treatment.
The Depressive Phenotype Induced in Adult Female Rats by Adolescent Exposure to THC is Associated with Cognitive Impairment and Altered Neuroplasticity in the Prefrontal Cortex
TLDR
To correlate memory impairment to altered neuroplasticity, level of marker proteins was investigated in the hippocampus and prefrontal cortex, the most relevant areas for learning and memory and revealed the presence of cognitive impairment in THC-induced depressive phenotype.
Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ-opioid and CB1-cannabinoid receptor involvement
TLDR
Results indicate that salvinorin A, as is sometimes reported in humans, exhibits rewarding effects, independently from its motor activity, suggesting the usefulness of the zebrafish model to study addictive behavior.
Delta9-tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats.
TLDR
It is demonstrated, for the first time, that low doses of Delta9-THC can act as an effective reinforcer in Wistar rats providing a reliable animal model of human marijuana abuse.
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