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- Publications
- Influence
Chronic Δ9-Tetrahydrocannabinol During Adolescence Provokes Sex-Dependent Changes in the Emotional Profile in Adult Rats: Behavioral and Biochemical Correlates
- T. Rubino, D. Vigano', +9 authors D. Parolaro
- Psychology, Medicine
- Neuropsychopharmacology
- 1 October 2008
Few and often contradictory reports exist on the long-term neurobiological consequences of cannabinoid consumption in adolescents. The endocannabinoid system plays an important role during the… Expand
Pharmacologic Rescue of Impaired Cognitive Flexibility, Social Deficits, Increased Aggression, and Seizure Susceptibility in Oxytocin Receptor Null Mice: A Neurobehavioral Model of Autism
- M. Sala, D. Braida, D. Lentini, M. Busnelli, B. Chini
- Psychology, Medicine
- Biological Psychiatry
- 1 May 2011
BACKGROUND
Oxytocin (OT) has been suggested as a treatment to improve social behavior in autistic patients. Accordingly, the OT (Oxt(-/-)) and the OT receptor null mice (Oxtr(-/-)) display… Expand
Potential anxiolytic‐ and antidepressant‐like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents
- D. Braida, V. Capurro, +4 authors M. Sala
- Chemistry, Medicine
- British journal of pharmacology
- 1 July 2009
Background and purpose: Drugs targeting brain κ‐opioid receptors produce profound alterations in mood. In the present study we investigated the possible anxiolytic‐ and antidepressant‐like effects… Expand
Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood
- T. Rubino, N. Realini, +8 authors D. Parolaro
- Psychology, Medicine
- Hippocampus
- 1 August 2009
Marijuana and hashish are the illicit drugs most frequently used by human adolescents. Given the continued neurodevelopment throughout adolescence, adolescents may be more vulnerable than adults to… Expand
The Depressive Phenotype Induced in Adult Female Rats by Adolescent Exposure to THC is Associated with Cognitive Impairment and Altered Neuroplasticity in the Prefrontal Cortex
- T. Rubino, N. Realini, +7 authors D. Parolaro
- Psychology, Medicine
- Neurotoxicity Research
- 28 February 2009
We recently demonstrated that Δ9-tetrahydrocannabinol (THC) chronic administration in female adolescent rats induces alterations in the emotional circuit ending in depressive-like behavior in… Expand
Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ-opioid and CB1-cannabinoid receptor involvement
- D. Braida, Valeria Limonta, +4 authors M. Sala
- Psychology, Medicine
- Psychopharmacology
- 12 January 2007
RationaleThe hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals.ObjectiveThe effects of salvinorin A on the… Expand
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors.
- D. Braida, E. Paladini, P. Griffini, M. Lamperti, A. Maggi, M. Sala
- Chemistry, Medicine
- European journal of pharmacology
- 29 April 1996
The potential of heptylphysostigmine tartrate (pyrrolo [2,3b] indol-5-ol, 3,3a,8,8a-hexahydro-1,3a,8-trimethylheptylcarbamate [ester, (3aS-cis)]) (MF201), a new second-generation cholinesterase… Expand
Cellular Mechanisms Underlying the Anxiolytic Effect of Low Doses of Peripheral Δ9-Tetrahydrocannabinol in Rats
- T. Rubino, M. Sala, +6 authors D. Parolaro
- Chemistry, Medicine
- Neuropsychopharmacology
- 7 February 2007
We investigated the effect of low doses of intraperitoneal Δ9-tetrahydrocannabinol (THC) on anxiety behavior in rats using the elevated plus maze (EPM). An anxiolytic effect was obtained in a range… Expand
Involvement of κ-Opioid and Endocannabinoid System on Salvinorin A-Induced Reward
- D. Braida, Valeria Limonta, V. Capurro, P. Fadda, M. Sala
- Chemistry
- Biological Psychiatry
- 1 February 2008
Background The recreational drug, Salvinorin A, derived from the plant of Salvia divinorum, is a potent and selective κ-opioid receptor agonist. The abuse of selective k-agonists is a novel… Expand
Neurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish
- D. Braida, A. Donzelli, +4 authors M. Sala
- Biology, Medicine
- Psychopharmacology
- 1 March 2012
RationaleOxytocin (OT) and arginine-vasopressin (AVP) regulate social behavior in mammals. Zebrafish (Danio rerio) allows higher throughput and ease in studying human brain disorders.ObjectivesThis… Expand