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Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia
Background Reduced hippocampal volume is a consistently described structural abnormality in schizophrenia but its cause and timing are not known. Aims To examine the relationship of duration ofExpand
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Role-Playing and Real-Time Strategy Games Associated with Greater Probability of Internet Gaming Disorder
Research indicates that a small subset of those who routinely play video games show signs of pathological habits, with side effects ranging from mild (e.g., being late) to quite severe (e.g., losingExpand
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Pharmacokinetics and safety assessments of high-dose and 4-week treatment with S-3304, a novel matrix metalloproteinase inhibitor, in healthy volunteers.
AIMS To investigate the tolerability, safety and pharmacokinetics of S-3304 in healthy volunteers treated with high doses of S-3304 for 28 days. METHODS Thirty-two healthy volunteers wereExpand
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Possible Opioid Shopping and its Correlates
Background: We created an operational definition of possible opioid shopping in US commercial health insurance data and examined its correlates. Methods: The population consisted of 264,204 treatmentExpand
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The MOBILE Study—A Phase IIa Enriched Enrollment Randomized Withdrawal Trial to Assess the Analgesic Efficacy and Safety of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Patients with
Abstract Objective To evaluate the analgesic efficacy and safety of ASP8477 in patients with peripheral neuropathic pain (PNP). Design Enriched enrollment randomized withdrawal. Setting Centers inExpand
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Safety and Efficacy of Fidaxomicin and Vancomycin in Children and Adolescents with Clostridioides (Clostridium) difficile Infection: A Phase 3, Multicenter, Randomized, Single-blind Clinical Trial
Abstract Background Fidaxomicin, a narrow-spectrum antibiotic approved for Clostridioides (Clostridium) difficile infection (CDI) in adults, is associated with lower rates of recurrence thanExpand
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Changes in HLA-DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers.
The infusion of a low dose of endotoxin into healthy subjects triggers a complex inflammatory response but the intricacies of which, despite extensive research, are still being unraveled. NineExpand
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LB12. Safety and Efficacy of Fidaxomicin and Vancomycin in Pediatric Patients with Clostridium difficile Infection: Phase III, Multicenter, Investigator-blind, Randomized, Parallel Group (SUNSHINE)
Abstract Background Clostridium difficile infection (CDI), a common cause of antibiotic-associated diarrhea, leads to substantial healthcare burden. In children and young adults, the incidence of CDIExpand
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