D. Bowen

Publications15
h-index11
Citations2,100
Highly Influential Citations132
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The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo
Formation of neuromuscular synapses requires a series of inductive interactions between growing motor axons and differentiating muscle cells, culminating in the precise juxtaposition of a highly… Expand
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Agrin Acts via a MuSK Receptor Complex
Formation of th neuromuscular junction depends upon reciprocal inductive interactions between the developing nerve and muscle, resulting in the precise juxtaposition of a differentiated nerve… Expand
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Dystroglycan binds nerve and muscle agrin
Neurally released agrin is thought to cluster acetylcholine receptors (AChRs) and other synaptic proteins in the postsynaptic membrane during synaptogenesis at the neuromuscular junction. We have… Expand
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Localization and regulation of MuSK at the neuromuscular junction.
The receptor tyrosine kinase, MuSK, is required for the formation of the neuromuscular junction (NMJ) where MuSK becomes phosphorylated when exposed to neuronally synthesized isoforms of agrin. To… Expand
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Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: required role for the MuSK ectodomain?
Formation of the neuromuscular junction (NMJ) depends upon a nerve-derived protein, agrin, acting by means of a muscle-specific receptor tyrosine kinase, MuSK, as well as a required accessory… Expand
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A muscle cell variant defective in glycosaminoglycan biosynthesis forms nerve-induced but not spontaneous clusters of the acetylcholine receptor and the 43 kDa protein
Myotubes of the C2 mouse muscle cell line form clusters of ACh receptors (AChRs) at apparently random sites along their length when cultured alone, and near sites of nerve-muscle contact when… Expand
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Neural Agrin Activates a High-Affinity Receptor in C2 Muscle Cells that Is Unresponsive to Muscle Agrin
During synaptogenesis, agrin, released by motor nerves, causes the clustering of acetylcholine receptors (AChRs) in the skeletal muscle membrane. Although muscle α-dystroglycan has been postulated to… Expand
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Altered Glycosaminoglycan Chain Structure in a Variant of the C2 Mouse Muscle Cell Line
Abstract: Experiments on the S27 cell line, a variant of the C2 mouse muscle cell line that shows reduced incorporation of 35SO4 into proteoglycans, suggest that proteoglycans play a role in the… Expand
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A comparative study of cytological and physiological parameters of semen obtained from alcoholics and non-alcoholics.
Sixty subjects between the ages of 18 and 50 were used in this study. Thirty of these were known alcoholics undergoing detoxification and treatment while the remainder were non-alcoholics of known… Expand
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Lack of central sprouting of primary afferent fibers after ricin deafferentation
  • L. Pubols, D. Bowen
  • Biology, Medicine
  • The Journal of comparative neurology
  • 8 September 1988
A new deafferentation technique, the application of ricin to peripheral nerves, was used to test for collateral sprouting of undamaged primary afferent fibers within the adult mammalian spinal cord… Expand
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