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Gene Ontology: tool for the unification of biology
TLDR
The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing. Expand
Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
TLDR
A new basis for the construction of a genetic linkage map of the human genome is described, to develop, by recombinant DNA techniques, random single-copy DNA probes capable of detecting DNA sequence polymorphisms, when hybridized to restriction digests of an individual's DNA. Expand
Cluster analysis and display of genome-wide expression patterns.
TLDR
A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression, finding in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes of known similar function. Expand
Molecular portraits of human breast tumours
TLDR
Variation in gene expression patterns in a set of 65 surgical specimens of human breast tumours from 42 different individuals were characterized using complementary DNA microarrays representing 8,102 human genes, providing a distinctive molecular portrait of each tumour. Expand
Genomic expression programs in the response of yeast cells to environmental changes.
TLDR
Analysis of genomic expression patterns in the yeast Saccharomyces cerevisiae implicated the transcription factors Yap1p, as well as Msn2p and Msn4p, in mediating specific features of the transcriptional response, while the identification of novel sequence elements provided clues to novel regulators. Expand
Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization.
TLDR
A comprehensive catalog of yeast genes whose transcript levels vary periodically within the cell cycle is created, and it is found that the mRNA levels of more than half of these 800 genes respond to one or both of these cyclins. Expand
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
TLDR
Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups. Expand
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
TLDR
It is shown that there is diversity in gene expression among the tumours of DLBCL patients, apparently reflecting the variation in tumour proliferation rate, host response and differentiation state of the tumour. Expand
Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.
TLDR
A set of analytical methods that modify and extend the classical theory for mapping quantitative trait loci (QTLs) and allow a substantial reduction in the number of progeny that need to be scored with the DNA markers. Expand
Repeated observation of breast tumor subtypes in independent gene expression data sets
TLDR
The results strongly support the idea that many of these breast tumor subtypes represent biologically distinct disease entities. Expand
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