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Aerosolized amphotericin B inhalations as prophylaxis of invasive aspergillus infections during prolonged neutropenia: results of a prospective randomized multicenter trial.
TLDR
No benefit is observed from prophylactic aeroAmB inhalations, but the overall incidence of IA infections was low, in contrast to other nonrandomized trials.
Pharmacokinetics of liposomal amphotericin B (Ambisome) in critically ill patients
TLDR
The liposomal formulation of amphotericin B significantly reduces the volume of drug distribution, thereby allowing for greater drug concentrations in serum, and the low toxicity of AmBisome therefore cannot readily be explained by its serum pharmacokinetics.
Enhanced pulmonary accumulation of liposomal amphotericin B (AmBisome) in acute liver transplant failure.
TLDR
Failure of the liver as a major component of the reticuloendothelial system may cause elevated plasma concentrations of liposomal amphotericin B and may enhance deposition ofliposomes in the lungs as a substitutive clearing organ.
High efficacy of gemcitabine and cisplatin in patients with predominantly anthracycline- and taxane-pretreated metastatic breast cancer
TLDR
Combination chemotherapy with gemcitabine and cisplatin given on 2 out of 3 weeks is well tolerated and active in heavily pretreated patients with MBC, even after prior exposure to anthracyclines and taxanes.
Serum pharmacology of amphotericin B applied in lipid emulsions
TLDR
A comparative pharmacokinetic analysis with data for a single patient treated with AmB/L demonstrated that hemodialysis did not significantly affect the disposition of amphotericin B, and lower peak concentrations and AUC values in serum and a correspondingly faster deposition of Amb/L in tissues may at least partly explain the lower toxicity of AmB /L.
Palliative chemotherapy for patients 70 years of age and older with metastatic colorectal cancer: a single-centre experience.
TLDR
Exposure to 1 or more doublet chemotherapies for mcrc was associated with better outcomes in non-trial patients 70 years of age and older, and Elderly patients treated with palliative chemotherapy and bevacizumab should be monitored carefully for arterial and venous thrombotic events.
Preoperative systemic etoposide/ifosfamide/doxorubicin chemotherapy combined with regional hyperthermia in high-risk sarcoma: a pilot study.
TLDR
The study (RHT-91) is continuing as a multicenter phase II trial in patients with high-risk soft-tissue sarcomas to test the potential of preoperative thermochemotherapy in regard to local control and survival.
Metronomic Oral Cyclophosphamide in Patients with Advanced Solid Tumors
TLDR
Low-dose oral Cy is a reasonable, generally well tolerated, and inexpensive option for patients with advanced solid tumors.
Eastern Canadian Gastrointestinal Cancer Consensus Conference 2016.
TLDR
This consensus statement addresses multiple topics, including follow-up and survivorship of patients with resected colorectal cancer, and Infectious complications of antineoplastic agents.
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