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Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices.
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Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions
Evidence for the existence of dopamine d2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor–receptor interactions
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Galanin receptor-1 modulates 5-hydroxtryptamine-1A signaling via heterodimerization.
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Bioluminescence resonance energy transfer methods to study G protein-coupled receptor-receptor tyrosine kinase heteroreceptor complexes.
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Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease
TLDR
The allosteric receptor–receptor interactions in G protein-coupled receptor (GPCR) heteroreceptor complexes of the central nervous system gave a new dimension to brain integration and neuropsychopharmacology and opened up a new world of D2R protomer targets in the listed heterocomplexes for treatment of positive, negative and cognitive symptoms of schizophrenia.
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Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions.
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Volume transmission and its different forms in the central nervous system
TLDR
It is proposed that monogamy in the female prairie vole may take place through an increase in oxytocin VT, especially in nucleus accumbens, and Acupuncture can produce VT signals by releasing transmitters and modulators from nerve terminals and mast cells.
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Adenosine–Dopamine Interactions in the Pathophysiology and Treatment of CNS Disorders
TLDR
The integrative receptor–receptor interactions in these RM give novel aspects on the pathophysiology and treatment strategies, based on combined treatments, for PD, schizophrenia, and drug addiction.
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Multiple D2 heteroreceptor complexes: new targets for treatment of schizophrenia
TLDR
The results indicate that the D2 is a hub receptor which interacts not only with many other G protein-coupled receptors (GPCRs) including DA isoreceptors but also with ion-channel receptors, receptor tyrosine kinases, scaffolding proteins and DA transporters.
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The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components
TLDR
A collective interaction network was constructed to provide insight into the overall topology of the GPCR heteromers and identify key players and a significant dominance of intrafamily versus interfamily connections is revealed.
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