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Structure and Control of the Actin Regulatory WAVE Complex
Members of the Wiskott–Aldrich syndrome protein (WASP) family control cytoskeletal dynamics by promoting actin filament nucleation with the Arp2/3 complex. The WASP relative WAVE regulatesExpand
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Crystal structure of the human sterol transporter ABCG5/ABCG8
ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral sterols in liver andExpand
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Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.
During antiviral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-phosphorylated STAT1 (PY-STAT1), which occurs via a subset of karyopherin alpha (KPNA) nuclearExpand
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Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35
Ebola viral protein 35 (VP35), encoded by the highly pathogenic Ebola virus, facilitates host immune evasion by antagonizing antiviral signaling pathways, including those initiated by RIG-I–likeExpand
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An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.
During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an RNA-template-bound form and a template-free form to provide the viral polymerase access to the RNA template. InExpand
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Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy
Significance The ring-shaped cohesin traps chromosomes inside its ring and regulates chromosome segregation during mitosis and transcription during interphase. The sister chromatid cohesion 2 proteinExpand
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In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.
The Ebola virus (EBOV) genome only encodes a single viral polypeptide with enzymatic activity, the viral large (L) RNA-dependent RNA polymerase protein. However, currently, there is limitedExpand
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Tiger Swallowtail Genome Reveals Mechanisms for Speciation and Caterpillar Chemical Defense.
Predicting phenotype from genotype represents the epitome of biological questions. Comparative genomics of appropriate model organisms holds the promise of making it possible. However, the highExpand
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Structure of the human cohesin inhibitor Wapl
Cohesin, along with positive regulators, establishes sister-chromatid cohesion by forming a ring to circle chromatin. The wings apart-like protein (Wapl) is a key negative regulator of cohesin andExpand
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Structural basis for Marburg virus VP35–mediated immune evasion mechanisms
Filoviruses, marburgvirus (MARV) and ebolavirus (EBOV), are causative agents of highly lethal hemorrhagic fever in humans. MARV and EBOV share a common genome organization but show importantExpand
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