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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
TLDR
It is demonstrated that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) — termed the SCID leukemia-initiating cell, or SL-IC — possesses the differentiate and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell. Expand
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells
TLDR
The characterization of human DNGR-1+ BDCA3hi DCs and the ability to grow them in vitro opens the door for exploiting this subset in immunotherapy. Expand
Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice.
TLDR
Detailed flow cytometric analysis of the marrow of highly engrafted mice demonstrated both lymphoid and myeloid differentiation, as well as the retention of a significant fraction of CD34(+) CD38(-) cells, which should be useful for identification of the cellular and molecular mechanisms that regulate primitive human hematopoietic cells. Expand
CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1‐inducing role of mesenteric lymph node macrophages during colitis
TLDR
It is demonstrated that, using CD64 expression, MΦs can be distinguished from DCs in the intestine of both mice and humans and how inflammation impacts this pathway is determined, and it is shown that T cell‐mediated colitis is associated with massive recruitment of monocytes to the intestine and the mesenteric lymph node (MLN). Expand
Expansion of human SCID-repopulating cells under hypoxic conditions.
TLDR
The use of low O2 levels to enhance the survival and/or self-renewal of human BM HSCs in vitro represents an important advance and could have valuable clinical implications. Expand
Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells.
TLDR
Evidence that anti-CD38 antibodies have a profound inhibitory effect on engraftment of cord blood and leukemia cells is presented and it is demonstrated that the CD34(+)CD38(+) fraction of certain acute myeloid leukemia samples contains all, or at least most, leukemia-initiating cell capacity. Expand
A newly discovered class of human hematopoietic cells with SCID-repopulating activity
TLDR
A newly discovered human repopulating cell is identified that initiates multilineage hematopoiesis in NOD/SCID mice and demonstrates complexity of the organization of the human stem- cell compartment and has important implications for clinical applications involving stem-cell transplantation. Expand
Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.
TLDR
It is shown that CD33, CD13, and CD123, well-established myeloid markers, are expressed on human long-term repopulating cells from cord blood and bone marrow, indicating that leukemic stem cells (LSCs) express this antigen. Expand
Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction.
TLDR
The data indicate that the phenotype of LICs is more heterogeneous than previously realized and can vary even within a single sample, which may make them particularly difficult to eradicate using therapies targeted against surface antigens. Expand
Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells
TLDR
It is reported that BMPs regulate the proliferation and differentiation of highly purified primitive human hematopoietic cells from adult and neonatal sources and a powerful model system for studying the biological mechanism of BMP action using primary human cells. Expand
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