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- Publications
- Influence
Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease.
- M. Longhi, Y. Ma, D. Bogdanos, P. Cheeseman, G. Mieli-Vergani, D. Vergani
- Biology, Medicine
- Journal of hepatology
- 1 July 2004
BACKGROUND/AIMS
CD4(+) lymphocytes constitutively expressing the IL-2-receptor alpha-chain (CD25) regulate the activation of CD4 and CD8 autoreactive T-cells by suppressing their proliferation and… Expand
Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease
- Y. Ma, M. Okamoto, +7 authors D. Vergani
- Medicine
- Hepatology
- 1 March 2002
Prevalence and clinical relevance of antibodies to soluble liver antigen (tRNP(Ser)Sec/SLA) in autoimmune hepatitis (AIH) have been investigated using partially purified or prokaryotically expressed… Expand
Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis.
- M. Longhi, Y. Ma, +5 authors D. Vergani
- Biology, Medicine
- Journal of autoimmunity
- 1 August 2005
BACKGROUND AND AIMS
CD4 T lymphocytes constitutively expressing the IL-2-receptor alpha-chain (CD25) (T-regs) are central to self-tolerance maintenance, preventing the proliferation and effector… Expand
Pathogenesis of autoimmune hepatitis.
- D. Vergani, K. Choudhuri, D. Bogdanos, G. Mieli-Vergani
- Biology, Medicine
- Clinics in liver disease
- 1 December 2011
Autoimmune hepatitis is initiated by CD4 T cells that recognize self-antigen. The effector cells differentiate into functional phenotypes according to cytokines in the microenvironment and the nature… Expand
Cytochrome P4502D6193–212: A New Immunodominant Epitope and Target of Virus/Self Cross-Reactivity in Liver Kidney Microsomal Autoantibody Type 1-Positive Liver Disease 1
- N. Kerkar, Kaushik Choudhuri, +7 authors D. Vergani
- Biology, Medicine
- The Journal of Immunology
- 1 February 2003
Cytochrome P4502D6 (CYP2D6), target of liver kidney microsomal autoantibody type 1 (LKM1), characterizes autoimmune hepatitis type 2 (AIH2) but is also found in patients with chronic hepatitis C… Expand
Helicobacter pylori and autoimmune disease: cause or bystander.
- D. Smyk, Andreas L. Koutsoumpas, M. Mytilinaiou, E. Rigopoulou, L. Sakkas, D. Bogdanos
- Medicine
- World journal of gastroenterology
- 21 January 2014
Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for gastric cancer. This pathogen has also been considered a potential trigger of gastric autoimmunity,… Expand
Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2.
- Y. Ma, D. Bogdanos, +6 authors D. Vergani
- Biology, Medicine
- Gastroenterology
- 1 March 2006
BACKGROUND & AIMS
Autoimmune hepatitis type 2 (AIH-2), a severe juvenile liver disorder of unknown etiology and pathogenesis, is characterized by liver-kidney microsomal antibody type 1 targeting… Expand
Autoantibodies and their antigens in autoimmune hepatitis.
- D. Bogdanos, G. Mieli-Vergani, D. Vergani
- Medicine
- Seminars in liver disease
- 1 August 2009
Autoantibody detection assists in the diagnosis and allows differentiation of autoimmune hepatitis (AIH) type 1 (AIH-1), characterized by antinuclear antibody (ANA) and/or smooth muscle antibody… Expand
Key Residues of a Major Cytochrome P4502D6 Epitope Are Located on the Surface of the Molecule1
- Y. Ma, Mark George Thomas, +9 authors D. Vergani
- Biology, Medicine
- The Journal of Immunology
- 1 July 2002
Eukaryotically expressed CYP2D6 is the universal target of liver kidney microsomal Ab type 1 (LKM1) in both type 2 autoimmune hepatitis (AIH) and chronic hepatitis C virus (HCV) infection. In… Expand
Disease-specific autoantibodies in primary biliary cirrhosis.
- D. Bogdanos, L. Komorowski
- Medicine
- Clinica chimica acta; international journal of…
- 18 March 2011
Anti-mitochondrial autoantibodies (AMA) are specific markers of primary biliary liver cirrhosis (PBC), a cholestatic autoimmune disease which is characterised by a progressive destruction of the… Expand