D. Bogdanos

Publications396
h-index48
Citations8,508
Highly Influential Citations236
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Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease.
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Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease
TLDR
Anticonformational tRNP(Ser)Sec/SLA reactivity is frequent in type 1 and type 2 AIH and ASC, defining patients with a worse prognosis, and RLA was similarly disease‐specific but remarkably more sensitive than ELISA and immunoblot.
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Autoimmune liver serology: current diagnostic and clinical challenges.
TLDR
Liver diagnostic serology is a fast-expanding area of investigation as new purified and recombinant autoantigens, and automated technologies such as ELISAs and bead assays, become available to complement (or even compete) traditional immunofluorescence procedures.
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Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis.
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Pathogenesis of autoimmune hepatitis.
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Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2.
TLDR
Data imply that the T-cell response to CYP2D6 in AIH-2 is polyclonal, involves multiple effector types targeting different epitopes, and is associated with hepatocyte damage, knowledge that should form the basis for a more refined therapeutic approach.
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Liver immunology.
TLDR
The study of the immunological properties of liver and delineation of the microenvironment of the intrahepatic milieu in normal and diseased livers provides a platform to understand the hierarchy of a series of detrimental events that lead to immune-mediated destruction of the liver and the rejection of liver allografts.
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Cytochrome P4502D6193–212: A New Immunodominant Epitope and Target of Virus/Self Cross-Reactivity in Liver Kidney Microsomal Autoantibody Type 1-Positive Liver Disease 1
TLDR
The demonstrated similarity and cross-reactivity between CYP2D6193–212 and two unrelated viruses suggests that multiple exposure to viruses mimicking self may represent an important pathway to the development of autoimmunity.
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Helicobacter pylori and autoimmune disease: cause or bystander.
TLDR
The current evidence in support or against the role of H. pylori as a potential trigger of autoimmune rheumatic and skin diseases, as well as organ specific autoimmune diseases is discussed.
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Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis
TLDR
PBC specific ANA, in particular of the IgG3 isotype, are associated with a more severe disease course, possibly reflecting the peculiar ability of this isotype to engage mediators of damage.
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