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Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease
TLDR
Anticonformational tRNP(Ser)Sec/SLA reactivity is frequent in type 1 and type 2 AIH and ASC, defining patients with a worse prognosis, and RLA was similarly disease‐specific but remarkably more sensitive than ELISA and immunoblot.
Autoimmune liver serology: current diagnostic and clinical challenges.
TLDR
Liver diagnostic serology is a fast-expanding area of investigation as new purified and recombinant autoantigens, and automated technologies such as ELISAs and bead assays, become available to complement (or even compete) traditional immunofluorescence procedures.
Pathogenesis of autoimmune hepatitis.
Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2.
TLDR
Data imply that the T-cell response to CYP2D6 in AIH-2 is polyclonal, involves multiple effector types targeting different epitopes, and is associated with hepatocyte damage, knowledge that should form the basis for a more refined therapeutic approach.
Liver immunology.
TLDR
The study of the immunological properties of liver and delineation of the microenvironment of the intrahepatic milieu in normal and diseased livers provides a platform to understand the hierarchy of a series of detrimental events that lead to immune-mediated destruction of the liver and the rejection of liver allografts.
Cytochrome P4502D6193–212: A New Immunodominant Epitope and Target of Virus/Self Cross-Reactivity in Liver Kidney Microsomal Autoantibody Type 1-Positive Liver Disease 1
TLDR
The demonstrated similarity and cross-reactivity between CYP2D6193–212 and two unrelated viruses suggests that multiple exposure to viruses mimicking self may represent an important pathway to the development of autoimmunity.
Helicobacter pylori and autoimmune disease: cause or bystander.
TLDR
The current evidence in support or against the role of H. pylori as a potential trigger of autoimmune rheumatic and skin diseases, as well as organ specific autoimmune diseases is discussed.
Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis
TLDR
PBC specific ANA, in particular of the IgG3 isotype, are associated with a more severe disease course, possibly reflecting the peculiar ability of this isotype to engage mediators of damage.
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