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Impaired Homocysteine Metabolism and Atherothrombotic Disease
TLDR
Results from further prospective cohort studies and from on-going interventional trials will determine whether homocysteine-lowering therapies can contribute to the prevention and reduction of cardiovascular risk. Expand
Glucose and free radicals impair the antioxidant properties of serum albumin
TLDR
It is proposed that, considering the poor glucose control found in diabetics as well as the key role of oxidative stress in vascular complications, glycation‐mediated and free radical‐induced impairment of the antioxidant properties of albumin might be important parameters in vascular complication encountered in diabetes. Expand
The importance of proteins in defense against oxidation.
TLDR
This review examines the specific role of sulfur-containing amino acids in protein degradation and their possible interplay with the reversal of limited oxidative lesions, and the participation of proteins in the overall antioxidant defense is discussed, specifically the role of metallothionein as an intracellular antioxidant and that of albumin as a circulating antioxidant. Expand
Differential effects of cysteine and methionine residues in the antioxidant activity of human serum albumin
TLDR
It is proposed that Cys chiefly works as a free radical scavenger whereas Met mainly acts as a metal chelator in relation to anti-/prooxidant properties of HSA. Expand
Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids.
TLDR
It is concluded that folate deficiency can potentiate the coagulation pathway mediated by the macrophage TF as well as the platelet activation process and alter the circulating and cellular fatty acid composition and thus influenced the balance of the platelets eicosanoid synthesis. Expand
Hyperhomocysteinemia induced by folic acid deficiency and methionine load--applications of a modified HPLC method.
TLDR
The procedure described here represents an improvement of different HPLC methods and is suitable for routine analysis of total homocysteine and other aminothiols (cysteine, cysteinyl-glycine and glutathione) in biological samples, as required in clinical and research laboratories. Expand
Effect of a two-year supplementation with low doses of antioxidant vitamins and/or minerals in elderly subjects on levels of nutrients and antioxidant defense parameters.
TLDR
The data indicate that antioxidant defense in elderly subjects was improved with low doses of vit C, vit E and beta CA as studied by means of a functional test utilizing red blood cells challenged in vitro with free radicals. Expand
Enhanced platelet thromboxane synthesis and reduced macrophage-dependent fibrinolytic activity related to oxidative stress in oral contraceptive-treated female rats.
TLDR
The results suggest that besides the reported increase in clotting factors, platelet hyperactivity, possibly through a stimulated free radical-induced arachidonic acid metabolism, might be involved in the known high thrombogenic risk observed in OC users. Expand
Folic acid deficiency enhances oral contraceptive-induced platelet hyperactivity.
TLDR
The data of the present study suggest that in addition to cigarette smoking, inadequate folic acid intake might predispose those taking OC to vascular thrombosis. Expand
Molecular Mechanism of the Blockade of Plasma Cholesteryl Ester Transfer Protein by Its Physiological Inhibitor Apolipoprotein CI*
TLDR
It was concluded that the inhibition of CETP activity by apo CI is in direct link with its specific electrostatic properties, and the apoCI-mediated reduction in the binding properties of lipoproteins results in weaker CETP-HDL interactions and fewer cholesteryl ester transfers. Expand
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