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Brain-derived neurotrophic factor.
Since the purification of BDNF in 1982, a great deal of evidence has mounted for its central roles in brain development, physiology, and pathology. Aside from its importance in neural development and… Expand
Idiopathic Intracranial Hypertension
OBJECTIVEThe history, diagnosis, and therapy of idiopathic intracranial hypertension (IIH) (pseudotumor cerebri) are reviewed. Theories of pathogenesis are considered, the clinical presentation is… Expand
Risk Factors for Hemorrhage during Microelectrode-guided Deep Brain Stimulator Implantation for Movement Disorders
OBJECTIVE:Although hemorrhage is a well-known complication of microelectrode-guided deep brain stimulation (DBS) surgery, risk factors for the development of hemorrhage have not been well defined. We… Expand
Analysis of Astroglial K+ Channel Expression in the Developing Hippocampus Reveals a Predominant Role of the Kir4.1 Subunit
- G. Seifert, K. Hüttmann, +4 authors C. Steinhäuser
- Biology, Medicine
- The Journal of Neuroscience
- 10 June 2009
Astrocytes in different brain regions display variable functional properties. In the hippocampus, astrocytes predominantly express time- and voltage-independent currents, but the underlying ion… Expand
In Vivo Measurement of Brain Extracellular Space Diffusion by Cortical Surface Photobleaching
- D. Binder, M. Papadopoulos, P. Haggie, A. Verkman
- Chemistry, Medicine
- The Journal of Neuroscience
- 15 September 2004
Molecular diffusion in the brain extracellular space (ECS) is an important determinant of neural function. We developed a brain surface photobleaching method to measure the diffusion of fluorescently… Expand
BDNF and epilepsy: too much of a good thing?
Various studies have shown that brain-derived neurotrophic factor (BDNF) increases neuronal excitability and is localized and upregulated in areas implicated in epileptogenesis. Seizure activity… Expand
New insights into water transport and edema in the central nervous system from phenotype analysis of aquaporin-4 null mice
Aquaporin-4 (AQP4) is the major water channel in the CNS. Its expression at fluid-tissue barriers (blood-brain and brain-cerebrospinal fluid barriers) throughout the brain and spinal cord suggests a… Expand
Modern neurosurgery for psychiatric disorders.
OBJECTIVE The evolution, rationale, and results of modern functional neurosurgery to treat psychiatric disorders are documented. The potential benefits of neurosurgical treatment for selected,… Expand
Three distinct roles of aquaporin-4 in brain function revealed by knockout mice.
- A. Verkman, D. Binder, O. Bloch, K. Auguste, M. Papadopoulos
- Biochimica et biophysica acta
- 1 August 2006
Aquaporin-4 (AQP4) is expressed in astrocytes throughout the central nervous system, particularly at the blood-brain and brain-cerebrospinal fluid barriers. Phenotype analysis of transgenic mice… Expand
Functional changes in astroglial cells in epilepsy
Epilepsy comprises a group of disorders characterized by the periodic occurrence of seizures, and pathologic specimens from patients with temporal lobe epilepsy demonstrate marked reactive gliosis.… Expand