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Distribution and diversity of Na-K-Cl cotransport proteins: a study with monoclonal antibodies.
The Na-K-Cl cotransporter (NKCC) is present in most animal cells where it functions in cell volume homeostasis and epithelial salt transport. We developed six monoclonal antibodies (designated T4,Expand
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A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.
Mutations in the inositol 5-phosphatase OCRL are responsible for Lowe syndrome, whose manifestations include mental retardation and renal Fanconi syndrome. OCRL has been implicated in membraneExpand
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Monoclonal antibody to Na,K-ATPase: immunocytochemical localization along nephron segments.
To obtain a highly specific reagent that could be utilized for ultrastructural localization of Na,K-ATPase, monoclonal antibodies were produced using microsomal preparations of outer renal medulla ofExpand
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Monoclonal antibodies for high-resolution localization of NHE3 in adult and neonatal rat kidney.
Previous immunochemical studies have shown that NHE3 is an apical Na+/H+ exchanger in some renal epithelia. The purpose of the present study was to develop high-affinity, isoform-specific monoclonalExpand
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NHE3: a Na+/H+ exchanger isoform of renal brush border.
Na+/H+ exchangers in the brush-border (luminal, apical) membrane of renal proximal tubules are responsible for active, transcellular reabsorption of NaHCO3 and NaCl. Although well characterizedExpand
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Sodium/Hydrogen Exchanger Gene Defect in Slow-Wave Epilepsy Mutant Mice
The "housekeeping" sodium/hydrogen exchanger, NHE1, mediates the electroneutral 1:1 exchange of Na+ and H+ across the plasma membrane. NHE1 is ubiquitous and is studied extensively for regulation ofExpand
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Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase
The gamma subunit of the Na,K-ATPase is a small membrane protein that copurifies with the alpha and beta subunits of the enzyme. Strong evidence that the gamma subunit is a component of theExpand
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Linking Receptor-mediated Endocytosis and Cell Signaling
Megalin, a member of the low density lipoprotein receptor gene family, is required for efficient protein absorption in the proximal tubule. Recent studies have shown that the low density lipoproteinExpand
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Immunolocalization of AE2 anion exchanger in rat kidney.
The cellular and subcellular localizations of the AE2 anion exchanger in rat kidney have remained elusive despite detection of moderately abundant AE2 mRNA and AE2 polypeptide in all kidney regions.Expand
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Active (9.6 S) and Inactive (21 S) Oligomers of NHE3 in Microdomains of the Renal Brush Border*
We have previously shown that Na+-H+ exchanger isoform NHE3 exists as both 9.6 and 21 S (megalin-associated) oligomers in the renal brush border (1). To characterize the oligomeric forms of the renalExpand
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