• Publications
  • Influence
Overview of the therapeutic potential of piplartine (piperlongumine).
TLDR
It is concluded that piplartine is effective for use in cancer therapy and its safety using chronic toxicological studies should be addressed to support the viability of clinical trials. Expand
In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper.
TLDR
Histopathological and morphological analyses of the tumor and the organs, including liver, spleen, and kidney, were performed in order to evaluate the toxicological aspects of the treatment with these amides and it was shown that both organs were reversibly affected by piplartine and piperine treatment, but in a different way. Expand
In vitro and in vivo antitumor effect of 5‐FU combined with piplartine and piperine
TLDR
Piplartine may enhance the therapeutic effectiveness of chemotherapeutic drugs, and moreover, this combination could improve immunocompetence hampered by 5‐FU, according to the findings. Expand
Antitumor properties of a sulfated polysaccharide from the red seaweed Champia feldmannii (Diaz‐Pifferer)
TLDR
Cf‐PLS has some interesting anticancer activity that could be associated with its immunostimulating properties, and acts as an immunomodulatory agent, raising theproduction of specific antibodies, and increasing the production of OVA‐specific antibodies. Expand
In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species
TLDR
Piperlonguminine did not show any significant in vitro cytotoxic effect at experimental exposure levels, but showed an in vivo antitumor effect, reinforcing the anticancer potential of spice components. Expand
Antitumour properties of the leaf essential oil of Xylopia frutescens Aubl. (Annonaceae).
TLDR
The essential oil was dominated by sesquiterpene constituents and has some interesting anticancer activity. Expand
Antiproliferative Effects of Two Amides, Piperine and Piplartine, from Piper Species
TLDR
None of the tested substances induced hemolysis of mouse erythrocytes, suggesting that the cytotoxicity of piplartine and piperine was not related to membrane damage. Expand
Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways.
TLDR
It is suggested that piplartine can suppress leukemia growth and reduce cell survival, triggering both apoptosis and/or necrosis, depending on the concentration used. Expand
Antitumor Activity of the Essential Oil from the Leaves of Croton regelianus and Its Component Ascaridole
TLDR
Ascaridole has an interesting antitumor activity in sarcoma 180 murine model, probably related to the described cytotoxic activity, and, moreover, its presence in the essential oil from the leaves of C. regelianus could explain, at least in part, the ethnopharmacological use of this plant in the treatment of cancer. Expand
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
TLDR
The essential oil showed significant in vitro and in vivo antitumor activity in this study, and displayed in vitro cytotoxicity against all three tumor cell lines tested. Expand
...
1
2
3
4
5
...