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Fucoxanthin, Tetraprenylated Toluquinone and Toluhydroquinone Metabolites from Sargassum heterophyllum Inhibit the in vitro Growth of the Malaria Parasite Plasmodium falciparum
Abstract In the course of our search for antimalarial leads from marine algae, four metabolites, sargaquinoic acid, sargahydroquinoic acid, sargaquinal and fucoxanthin, were isolated from the SouthExpand
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Cytotoxic pyrroloiminoquinones from four new species of South African latrunculid sponges.
An examination of organic extracts of four new species of South African latrunculid sponges, Tsitsikamma pedunculata, T. favus, Latrunculia bellae, and Strongylodesma algoaensis, yielded 13 known andExpand
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Identification and in vitro anti-esophageal cancer activity of a series of halogenated monoterpenes isolated from the South African seaweeds Plocamium suhrii and Plocamium cornutum.
Five known (1, 2, 4, 6 and 7) halogenated monoterpenes together with 1Z,3R∗,4S∗,5E,7Z)-1-bromo-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene (3) andExpand
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Halogenated monoterpene aldehydes from the South African marine alga Plocamium corallorhiza.
Four new halogenated monoterpene aldehydes (1-4) have been isolated from the South African marine red alga Plocamium corallorhiza, along with the known compoundsExpand
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Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay
BackgroundThe cancer stem cell (CSC) theory proposes that tumours arise from and are sustained by a subpopulation of cells with both cancer and stem cell properties. One of the key hallmarks of CSCsExpand
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Plocoralides A-C, polyhalogenated monoterpenes from the marine alga Plocamium corallorhiza.
Three new polyhalogenated monoterpenes, plocoralides A-C (1-3) along with three known compounds (4-6) have been isolated from the organic extract of the red alga P. corallorhiza. Structures of theExpand
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Antiplasmodial halogenated monoterpenes from the marine red alga Plocamium cornutum.
In our continuing search for antimalarial leads from South African marine organisms we have examined the antiplasmodial organic extracts of the endemic marine red alga Plocamium cornutum (Turner)Expand
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Novel polypropionates from the South African marine mollusc Siphonaria capensis
Abstract The endemic South African pulmonate mollusc Siphonaria capensis yielded C-2 epimeric mixtures of the known polypropionate metabolites siphonarienfuranone (1) and its Z-isomer (2), and threeExpand
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Ten Years of Marine Natural Products Research at Rhodes University
Marine invertebrates, algae and microorganisms produce a plethora of structurally unique and biologically active secondary metabolites. The ecological roles of these natural products, although notExpand
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Critical assessment of voltammetry for rapid screening of antioxidants in marine algae.
Abstract Voltammetric methods of analysis represent an attractive option for rapid screening of large numbers of plant samples in the search for novel antioxidants. However, the technique has notExpand
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