Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock
- D. Berson, Felice A. Dunn, M. Takao
- BiologyScience
- 8 February 2002
It is shown that retinal ganglion cells innervating the SCN are intrinsically photosensitive, and depolarized in response to light even when all synaptic input from rods and cones was blocked.
Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity
It is shown that melanopsin is present in cell bodies, dendrites, and proximal axonal segments of a subset of rat RGCs, most likely the visual pigment of phototransducing R GCs that set the circadian clock and initiate other nonâimage-forming visual functions.
Central projections of melanopsinâexpressing retinal ganglion cells in the mouse
- S. Hattar, Monica Kumar, D. Berson
- BiologyThe Journal of comparative neurology
- 20 July 2006
Staining patterns after monocular enucleation revealed that the projections of these cells are overwhelmingly crossed except for the projection to the SCN, which is bilaterally symmetrical, and that other ganglion cells do contribute at least some retinal input to these targets.
Measuring and using light in the melanopsin age
- R. Lucas, S. Peirson, G. Brainard
- BiologyTrends in Neurosciences
- 31 January 2014
Melanopsin-Expressing Retinal Ganglion-Cell Photoreceptors: Cellular Diversity and Role in Pattern Vision
- J. Ecker, O. N. Dumitrescu, S. Hattar
- BiologyNeuron
- 15 July 2010
Diminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice
It is reported that in mice with the melanopsin gene ablated, RGCs retrograde-labeled from the suprachiasmatic nuclei were no longer intrinsically photosensitive, although their number, morphology, and projections were unchanged.
Melanopsin cells are the principal conduits for rodâcone input to non-image-forming vision
- A. D. GĂźler, J. Ecker, S. Hattar
- BiologyNature
- 1 May 2008
It is indicated that light signals for irradiance detection are dissociated from pattern vision at the retinal ganglion cell level, and animals that cannot detect light for NIF functions are still capable of image formation.
Morphology and mosaics of melanopsinâexpressing retinal ganglion cell types in mice
- D. Berson, A. Castrucci, I. Provencio
- BiologyThe Journal of comparative neurology
- 1 July 2010
Using enhanced immunohistochemistry, a fuller description of murine cell types expressing melanopigment is provided, their contribution to the plexuses of melanopsin dendrites, and mosaics formed by each type are provided.
Form and Function of the M4 Cell, an Intrinsically Photosensitive Retinal Ganglion Cell Type Contributing to Geniculocortical Vision
- M. E. Estevez, P. Fogerson, D. Berson
- BiologyJournal of Neuroscience
- 26 September 2012
The first in-depth characterization of M4 cells is provided, including their structure, function, and central projections in mouse retina, which shows robust, sustained, synaptically driven ON responses and dendritic stratification in the ON sublamina of the inner plexiform layer.
Synaptic influences on rat ganglionâcell photoreceptors
- Kwoon Y. Wong, Felice A. Dunn, Dustin M. Graham, D. Berson
- BiologyJournal of Physiology
- 1 July 2007
These extrinsic ipRGC light responses can explain some of the previously reported properties of circadian photoentrainment and other nonâimageâforming visual behaviours, and also extend their temporal bandpass to higher frequencies.
...
...