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The role of the immune system in the generation of neuropathic pain
Persistent pain is a sequela of several neurological conditions with a primary immune basis, such as Guillain-Barré syndrome and multiple sclerosis. Additionally, diverse forms of injury to theExpand
Neuropathic pain: an updated grading system for research and clinical practice
Abstract The redefinition of neuropathic pain as “pain arising as a direct consequence of a lesion or disease affecting the somatosensory system,” which was suggested by the International AssociationExpand
Neuroinflammation and the generation of neuropathic pain.
Inflammation is the process by which an organism responds to tissue injury involving both immune cell recruitment and mediator release. Diverse causes of neuropathic pain are associated withExpand
New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain
Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic complications create a substantial burden on both the afflicted patients and society as a whole. Given the enormity ofExpand
The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule
Evidence suggests that nerve growth factor (NGF) may function as a mediator of some persistent pain states. We have used a synthetic protein, trkA-IgG, to sequester endogenous NGF and block theExpand
A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy
Summary Rats treated with the HIV antiretroviral drug stavudine revealed alterations in complex ethologically relevant behaviours associated with pain and a distinct peripheral nerve neuropathology.Expand
A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome
Summary Human monogenic pain syndromes have provided important insights into the molecular mechanisms that underlie normal and pathological pain states. We describe an autosomal-dominant familialExpand
The Glial Cell Line-Derived Neurotrophic Factor Family Receptor Components Are Differentially Regulated within Sensory Neurons after Nerve Injury
Glial cell line-derived neurotrophic factor (GDNF) has potent trophic effects on adult sensory neurons after nerve injury and is one of a family of proteins that includes neurturin, persephin, andExpand
Conduction Failure following Spinal Cord Injury: Functional and Anatomical Changes from Acute to Chronic Stages
In the majority of spinal cord injuries (SCIs), some axonal projections remain intact. We examined the functional status of these surviving axons since they represent a prime therapeutic target.Expand