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Oral Cavity and Esophageal Carcinogenesis Modeled in Carcinogen-Treated Mice
TLDR
Interestingly, similar features of carcinogenesis, including multiple, large exophytic papillary squamous tumors and invasive squamous cell carcinomas, increased bromodeoxyuridine staining, and increased K14 expression, were also observed in the esophagi of 4-NQO-treated mice. Expand
A human- and male-specific protocadherin that acts through the wnt signaling pathway to induce neuroendocrine transdifferentiation of prostate cancer cells.
TLDR
Transfection of human prostate cancer cells with PCDH-PC or culture of these cells in androgen-free medium activates wnt signaling as assessed by nuclear accumulation of beta-catenin, increased expression of luciferase from a reporter vector promoted by Tcf binding elements and increased expressionof wnt target genes. Expand
Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells
TLDR
This work improved and applied the experimental-computational perturbation biology method and proposed an anti-cancer strategy of co-targeting a specific upstream alteration and a general downstream point of vulnerability to prevent or overcome resistance to targeted drugs. Expand
A Multi-Method Approach for Proteomic Network Inference in 11 Human Cancers
TLDR
Mapping the consensus network interactions to Reactome gene lists confirms the pan-cancer importance of signal transduction pathways, innate and adaptive immune signaling, cell cycle, metabolism, and DNA repair; and also suggests several biological processes that may be specific to a subset of tumor types. Expand
Complex regulation of human androgen receptor expression by Wnt signaling in prostate cancer cells
TLDR
The data indicate that the hAR gene is a direct target of LEF-1/TCF transcriptional regulation in PCa cells but also show that the expression of the har protein is suppressed by a degradation pathway regulated by cross-talk of Wnt to Akt that is likely mediated by Wnt-directed degradation of the B regulatory subunit of protein phosphatase, PP2A. Expand
Anti-prostate cancer activity of a beta-carboline alkaloid enriched extract from Rauwolfia vomitoria.
TLDR
The Rauwolfia vomitoria extract significantly suppressed the growth and cell cycle progression of LNCaP cells, in vitro and in vivo. Expand
The use of herbal and over-the-counter dietary supplements for the prevention of prostate cancer
TLDR
There is insufficient clinical evidence to support the widespread use of these dietary supplements for chemoprevention of prostate cancer, although ongoing clinical trials of the most promising vitamins and minerals are approaching conclusion. Expand
Zyflamend®, a Unique Herbal Preparation With Nonselective OX Inhibitory Activity, Induces Apoptosis of Prostate Cancer Cells That Lack COX-2 Expression
TLDR
The data suggests that the effects of Zyflamend on human prostate cancer cell line LNCaP are likely due to COX-independent mechanisms potentially involving enhanced expression of p21 and reduced expression of AR, pStat3, and pPKCα/β. Expand
beta-carboline alkaloid-enriched extract from the amazonian rain forest tree pao pereira suppresses prostate cancer cells.
TLDR
Although this study supports the idea that a pao pereira bark extract has activity against human prostate cancer, in vivo results suggest that its potential effectiveness in prostate cancer treatment may be limited to a narrow dose range. Expand
The use of herbal and over-the-counter dietary supplements for the prevention of prostate cancer
TLDR
There is insufficient clinical evidence to support the widespread use of these dietary supplements for chemoprevention of prostate cancer, although ongoing clinical trials of the most promising vitamins and minerals are approaching conclusion. Expand
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