Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
- B. Chorley, Michelle R. Campbell, D. Bell
- BiologyNucleic Acids Research
- 11 May 2012
Validation of selected candidate genes using parallel ChIP techniques and in NRF2-silenced cell lines indicated that the expression of about two-thirds of the candidates are likely to be directly NRF1-dependent including retinoid X receptor alpha (RXRA), which has implications for response to retinoids treatments and adipogenesis.
Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution.
- M. Watson, R. Stewart, G. B. Smith, T. Massey, D. Bell
- BiologyCarcinogenesis
- 1 February 1998
The association between glutathione S-transferase (GST) activity as measured by 1-chloro-2,4-dinitrobenzene (CDNB) conjugation and genotype at exon 5 and exon 6 of the human GSTP1 gene was investigated in normal lung tissue obtained from 34 surgical patients, suggesting the possibility of GSTP 1 genotype-associated, ethnic differences in cancer susceptibility and chemotherapeutic response.
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.
- T. Sullivan-Klose, B. Ghanayem, J. Goldstein
- BiologyPharmacogenetics (London)
- 1 August 1996
The present data suggest that the incidence of the Leu359 allelic variant of CYP2C9 may account for the occurrence of poor metabolizers of tolbutamide.
450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy
- B. Joubert, S. HÃ¥berg, S. London
- Medicine, BiologyEnvironmental Health Perspectives
- 31 July 2012
The findings implicate epigenetic mechanisms in the pathogenesis of the adverse health outcomes associated with this important in utero exposure.
Association between glutathione S-transferase M1, P1, and T1 genetic polymorphisms and development of breast cancer.
- K. Helzlsouer, O. Selmin, D. Bell
- Biology, MedicineJournal of the National Cancer Institute
- 1 April 1998
It is suggested that genetic variability in members of the GST gene family may be associated with an increased susceptibility to breast cancer.
Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations.
- J. Goldstein, T. Ishizaki, D. Evans
- BiologyPharmacogenetics (London)
- 1 February 1997
This study examined whether the genotype predicted the phenotype in Japanese, Filipino and Saudi Arabian populations, and compared the frequencies of the defective CYP2C19 alleles in these populations with those found in European-Americans, Chinese-Taiwanese, and African-Americans from North Carolina.
Polymorphisms in the DNA repair gene XRCC1 and breast cancer.
- E. Duell, R. Millikan, D. Bell
- BiologyCancer Epidemiology, Biomarkers and Prevention
- 1 March 2001
The results suggest that XRRC1 codon 399 genotype may influence breast cancer risk, perhaps by modifying the effects of environmental exposures.
XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.
- R. Lunn, R. G. Langlois, L. Hsieh, C. Thompson, D. Bell
- BiologyCancer Research
- 1 June 1999
The results suggest that the Arg399Gln amino acid change may alter the phenotype of the XRCC1 protein, resulting in deficient DNA repair.
An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.
- J. Lavigne, K. Helzlsouer, J. Yager
- Biology, MedicineCancer Research
- 15 December 1997
The findings suggest that the allele encoding low activity COMT may be an important contributor to the postmenopausal development of breast cancer in certain women.
Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers.
- M. Deakin, J. Elder, R. Strange
- Biology, MedicineCarcinogenesis
- 1 April 1996
Data complement studies showing that GSTT1 null is associated with an increased susceptibility to total ulcerative colitis and suggests that this enzyme is important in the detoxification of unidentified xenobiotics in the large intestine are suggested.
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