• Publications
  • Influence
Integrated Genomic Analyses of Ovarian Carcinoma
TLDR
It is reported that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1,BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; and promoter methylation events involving 168 genes.
Ovarian cancer is a heterogeneous disease.
Early loss of heterozygosity on 17q in ovarian cancer. The Abe Ovarian Cancer Genetics Group.
TLDR
Comparison of all malignant tumours presenting with either localized or widespread FIGO stage I/II or widespread disease showed that, particularly on 17q, allele loss increases in the more advanced stages, and the findings suggest that an important tumour-suppressor gene may be located in the region 17q23-qter.
...
...