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Pharmacokinetics of ciprofloxacin after oral and intravenous administration in healthy volunteers
- W. Wingender, K. Graefe, W. Gau, D. Förster, D. Beermann, P. Schacht
- MedicineEuropean Journal of Clinical Microbiology
- 1 August 1984
The pharmacokinetics of ciprofloxacin (Bay o 9867) was examined after a single oral dose of 250 mg and a single intravenous dose of 100 mg respectively in six healthy male volunteers in an open,…
Ciprofloxacin absorption in different regions of the human gastrointestinal tract. Investigations with the hf-capsule.
- S. Harder, U. Fuhr, D. Beermann, A. Staib
- MedicineBritish journal of clinical pharmacology
- 1 July 1990
It is concluded that the main absorption site of ciprofloxacin is the upper gastrointestinal tract, up to the jejunum, which resulted in the greatest AUC in this study.
Comparative tumorigenicity of picene and dibenz[a,h]anthracene in the mouse.
This rare biological property of picene, which is a complete carcinogen, yet at most a very weak tumor initiateator, is explained in terms of its inefficient biotransformation to mutagenic and carcinogenic metabolites as compared to the strong tumor initiator DBA.
The pharmacokinetics of nitrendipine. I. Absorption, plasma concentrations, and excretion after single administration of [14C]nitrendipine to rats and dogs.
- H. Krause, H. Ahr, D. Beermann, H. Siefert, D. Suwelack, H. Weber
- 1 November 1988
Distinct sex-differences in the excretion pattern could be found in rats but not in mice, attributed to well-known sex differences of the metabolic capacities in rat liver.
Pharmacokinetics of the active metabolite of the prodrug repirinast in healthy Caucasian volunteers after a single oral dose
- D. Beermann, H. Schaefer, M. Wargenau, B. Heibel, Y. Sturm, J. Kuhlmann
- MedicineEuropean Journal of Clinical Pharmacology
The renal clearance of about 27 l/h suggests that BAY w 8199 is excreted by tubular secretion in addition to glomerular filtration, which is in line with previous studies of the active metabolite of the prodrug repirinast.
Effect of food on the pharmacokinetics of the active metabolite of the prodrug repirinast.
- H. Schaefer, D. Beermann, R. Horstmann, M. Wargenau, B. Heibel, J. Kuhlmann
- Chemistry, MedicineJournal of pharmaceutical sciences
The effect of food on the pharmacokinetics of the active metabolite of the new antiasthmatic drug repirinast was investigated in two different studies after oral administration of 300 mg of…
Liquid Chromatographic Analysis of Ciprofloxacin and Ciprofloxacin Metabolites in Body Fluids
Abstract An isocratic HPLC assay procedure for analysis of ciprofloxacin and three metabolites was developed. The procedure requires only dilution of bile, saliva, and urine samples prior to…
Mutagenicity of structurally related oxiranes: derivatives of benzene and its hydrogenated congeners.
The mutagenicities of 17 closely related oxiranes were determined in 4 tester strains and the influence of bromo and hydroxyl substitution on oxirane mutagenicity is discussed.
Absorption differences of ciprofloxacin along the human gastrointestinal tract determined using a remote-control drug delivery device (HF-capsule).
- A. Staib, D. Beermann, S. Harder, U. Fuhr, D. Liermann
- MedicineThe American journal of medicine
- 30 November 1989
The single-dose absorption kinetics of ciprofloxacin in different regions of the human gastrointestinal tract were investigated using a remote-control drug delivery device and it was concluded that the main absorption site is the upper part of the intestinal tract (duodenum, jejunum).
Bactericidal activity of ciprofloxacin, norfloxacin and ofloxacin in serum and urine after oral administration to healthy volunteers
Measurements of urine bactericidal activity showed that ciprofloxacin hat the highest titers during the early collection periods, whereas the prolonged excretion of ofloxacIn did not result in higher urine bactericide titers, compared to cIProfl oxacin.