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Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
CD39, or vascular adenosine triphosphate diphosphohydrolase, has been considered an important inhibitor of platelet activation. Unexpectedly, cd39-deficient mice had prolonged bleeding times withExpand
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A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state.
The activity of the coagulation system is regulated, in part, by the interaction of thrombin with the endothelial cell receptor thrombomodulin with subsequent generation of activated protein C andExpand
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Enzymatic synthesis of antithrombin III–binding heparan sulfate pentasaccharide
Heparan sulfate (HS) proteoglycans are crucial to numerous biological processes and pathological conditions, but to date only a few HS structures have been synthesized and characterized with regardExpand
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Chemoenzymatic Synthesis of Classical and Non-classical Anticoagulant Heparan Sulfate Polysaccharides*
Heparan sulfate (HS) polysaccharides interact with numerous proteins at the cell surface and orchestrate many different biological functions. Though many functions of HS are well established, only aExpand
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The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production.
The circulating blood platelet is produced by the bone marrow megakaryocyte. In response to a decrease in the platelet count, megakaryocytes increase in number and ploidy. Although this feedback loopExpand
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Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis.
Endothelial cell production of anticoagulant heparan sulfate (HS(act)) is controlled by the Hs3st1 gene, which encodes the rate-limiting enzyme heparan sulfate 3-O-sulfotransferase-1 (3-OST-1). InExpand
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The isolation and characterization of a specific antibody population directed against the prothrombin activation fragments F2 and F1 + 2.
We have raised antisera against human prothrombin activation fragment F2 in rabbits and have chromatographed the respective immunoglobulin G fractions on prothrombin-Sepharose, Pr1-Sepharose, andExpand
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Analysis of heparan sulfate oligosaccharides with ion pair-reverse phase capillary high performance liquid chromatography-microelectrospray ionization time-of-flight mass spectrometry.
Heparan sulfate, a cell surface bound glycosaminoglycan polysaccharide, has been implicated in numerous biological functions. Heparan sulfate molecules are highly complex and diverse, yet deceivinglyExpand
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The Involvement of Heparan Sulfate (HS) in FGF1/HS/FGFR1 Signaling Complex*
Fibroblast growth factor (FGF) signaling begins with the formation of a ternary complex of FGF, FGF receptor (FGFR), and heparan sulfate (HS). Multiple models have been proposed for the ternaryExpand
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A new strategy for defining critical functional groups on heparan sulfate
Heparan sulfate (HS) is a sulfated polysaccharide present on cell surfaces and in the extracellular matrix. Accumulating evidence shows that HS plays key roles in many biological systems byExpand
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