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Novel Structural Features in Candida albicans Hyphal Glucan Provide a Basis for Differential Innate Immune Recognition of Hyphae Versus Yeast*
TLDR
Hphal glucan induced robust immune responses in human peripheral blood mononuclear cells and macrophages via a Dectin-1-dependent mechanism and provided a structural basis for differential innate immune recognition of C. albicans yeast versus hyphae. Expand
Fish tissue quality in near-coastal areas of the Gulf of Mexico receiving point source discharges.
The objective of this study was to determine inorganic and organic contaminant concentrations in edible tissue of fish collected from eight coastal areas receiving wastewater discharges and from twoExpand
Ecosystem Responses to Extreme Natural Events: Impacts of Three Sequential Hurricanes in Fall 1999 on Sediment Quality and Condition of Benthic Fauna in the Neuse River Estuary, North Carolina
TLDR
Storm-related reductions in dissoved oxygen and salinity were the more likely causes of the observed benthic impacts, though it was not possible, based on these results, to separate storm effects from seasonal changes in the benthos and annual episodes of summer anoxia and hypoxia. Expand
International NMR-based environmental metabolomics intercomparison exercise.
TLDR
It is demonstrated that NMR-based metabolomics can generate data that are sufficiently comparable between laboratories to support its continued evaluation for regulatory environmental studies. Expand
Toxicological studies in tropical ecosystems: an ecotoxicological risk assessment of pesticide runoff in South Florida estuarine ecosystems.
A multiyear study in the C-111 canal system and associated sites in Florida Bay was undertaken to determine the potential pesticide risk that exists in South Florida. After the examination ofExpand
Integrating Omic Technologies into Aquatic Ecological Risk Assessment and Environmental Monitoring: Hurdles, Achievements, and Future Outlook
TLDR
Although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach. Expand
Platelets subvert T cell immunity against cancer via GARP-TGFβ axis
TLDR
It is concluded that platelets constrain T cell immunity through a GARP-TGFβ axis and suggest a combination of immunotherapy and platelet inhibitors as a therapeutic strategy against cancer. Expand
The effects of the contemporary-use insecticide (fipronil) in an estuarine mesocosm.
TLDR
It is suggested that fipronil may impact shrimp populations at low concentrations and further use in coastal areas should be carefully assessed. Expand
NMR-based microbial metabolomics and the temperature-dependent coral pathogen Vibrio coralliilyticus.
TLDR
The temperature-dependence of V. corallillyticus in regard to its metabolome was investigated and betaine, succinate, and glutamate were identified as metabolites that caused the greatest temperature-based separations in the PC scores plots. Expand
Metabolite profiling of a NIST Standard Reference Material for human plasma (SRM 1950): GC-MS, LC-MS, NMR, and clinical laboratory analyses, libraries, and web-based resources.
TLDR
The repeatability and intermediate precision analyses show that the SRM 1950 profiling is reproducible enough to consider this material as a good choice to distinguish between analytical and biological variability. Expand
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