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Differential Distribution of Three Members of a Gene Family Encoding Low Voltage-Activated (T-Type) Calcium Channels
TLDR
The results are consistent with the hypothesis that differential gene expression underlies pharmacological and physiological heterogeneity observed in neuronal T-type calcium currents, and they provide a molecular basis for the study of T- type channels in particular neurons. Expand
Respiratory control by ventral surface chemoreceptor neurons in rats
TLDR
In vivo and in vitro electrophysiological recordings are used to identify VMS neurons within the rat retrotrapezoid nucleus (RTN) that have characteristics befitting these elusive VMS chemoreceptors, and CO2-sensitive neurons of the RTN are identified. Expand
Synaptic control of motoneuronal excitability.
TLDR
A background description of motoneurons: their development, anatomical organization, and membrane properties, both passive and active, and a description of the major transmitter systems that affect mot oneuronal excitability, focusing on synaptic and cellular properties. Expand
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
TLDR
PANX1 is identified as a plasma membrane channel mediating the regulated release of find-me signals and selective plasma membrane permeability during apoptosis, and a new mechanism of PANX1 activation by caspases is identified. Expand
Development of glycinergic synaptic transmission to rat brain stem motoneurons.
TLDR
Glycinergic PSPs are therefore depolarizing and prolonged in neonate HMs and become faster and hyperpolarizing during the first two postnatal weeks. Expand
TASK-1, a Two–Pore Domain K+ Channel, Is Modulated by Multiple Neurotransmitters in Motoneurons
TLDR
It is shown that TASK-1, a two pore domain K+ channel, provides a prominent leak K+ current and target for neurotransmitter modulation in hypoglossal motoneurons (HMs) and also likely supports this action in other CNS neurons. Expand
Motoneurons Express Heteromeric TWIK-Related Acid-Sensitive K+ (TASK) Channels Containing TASK-1 (KCNK3) and TASK-3 (KCNK9) Subunits
TLDR
Heterodimeric TASK channels provide a substantial component of background K+ current in motoneurons with distinct modulatory properties and indicate that TasK-1 and TASk-3 subunits coassociate in functional channels. Expand
Multiple potassium conductances and their role in action potential repolarization and repetitive firing behavior of neonatal rat hypoglossal motoneurons.
TLDR
It is concluded that action potential repolarization and afterhyperpolarization are due to activation of pharmacologically distinct potassium conductances and that the mAHP requires the influx of extracellular calcium and is apamin sensitive. Expand
Expression of Phox2b by Brainstem Neurons Involved in Chemosensory Integration in the Adult Rat
TLDR
Observations suggest that Phox2b is expressed by an uninterrupted chain of neurons involved in the integration of peripheral and central chemoreception, which could explain why Phox1b mutations disrupt breathing automaticity during sleep without causing major impairment of respiration during waking. Expand
TASK Channels Determine pH Sensitivity in Select Respiratory Neurons But Do Not Contribute to Central Respiratory Chemosensitivity
TLDR
P pH sensitivity of neurons in the mouse retrotrapezoid nucleus (RTN) was fully maintained in a TASK null background, and pharmacological evidence indicated that a non-TASK K+ current contributes to chemosensitivity of RTN neurons, which are profoundly pH-sensitive and capable of driving respiratory output in response to local pH changes in vivo. Expand
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