• Publications
  • Influence
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
TLDR
A remarkable picture of tumor type specificity for histone H 3.3.3 driver alterations emerges, indicating that hist one H3. Expand
Recurrent PTPRB and PLCG1 mutations in angiosarcoma
TLDR
This work employed whole-genome, whole-exome and targeted sequencing to study the somatic changes underpinning primary and secondary angiosarcoma, and identified recurrent mutations in two genes, PTPRB and PLCG1, which are intimately linked to angiogenesis. Expand
The landscape of genomic alterations across childhood cancers
TLDR
The data suggest that 7–8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials. Expand
Glypican 3 expression in human nonneoplastic, preneoplastic, and neoplastic tissues: a tissue microarray analysis of 4,387 tissue samples.
TLDR
Tissue microarray technology revealed consistent expression of GPC3 in several tumors, including squamous cell carcinoma of the lung, testicular nonseminomatous germ cell tumors, and liposarcoma, underlining the role of G PC3 in hepatocarcinogenesis. Expand
Revised histopathological consensus classification of joint implant related pathology.
TLDR
This extended classification of joint implant related pathology is a practical histopathologic classification based on defined morphological criteria covering the complete spectrum of pathohistologic changes in periprosthetic tissues providing a stable and reproducible tool for the surgical pathologist. Expand
Histopathologic Features and Microsatellite Instability of Cancers of the Papilla of Vater and Their Precursor Lesions
TLDR
The findings indicate that the MSI-phenotype is an early event, which develops at the stage of adenoma and is reliably detectable in the precursor lesion, and is associated with a histopathologic phenotype in ampullary cancer, similar to the one that has been well described in colon cancer. Expand
Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
TLDR
It is implied that multiple oncogenic pathways drive chromosomal instability during osteosarcoma evolution and result in the acquisition of BRCA-like traits, which could be therapeutically exploited. Expand
Two Mitosis-Specific Antibodies, MPM-2 and Phospho-Histone H3 (Ser28), Allow Rapid and Precise Determination of Mitotic Activity
TLDR
Both MPM-2 and PHH3 were subjectively rated by all pathologists involved in this study to be very helpful in mitotic counting, especially in melanocytic and mesenchymal lesions but less so in epithelial tumors. Expand
Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast‐rich mimics
TLDR
Overall, the observations suggest that the presence of H3F3A p.Gly34 mutations appear to be an almost essential feature of GCT that will aid pathological evaluation of bone tumours, especially when confronted with small needle core biopsies. Expand
Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial
TLDR
Hyaline-like cartilage tissues, engineered from autologous nasal chondrocytes, can be used clinically for repair of articular cartilage defects in the knee and were improved significantly from before surgery to 24 months after surgery. Expand
...
1
2
3
4
5
...