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Cerebellar Degeneration in Cattle Grazing Solanum Bonariense (“Naranjillo”) in Western Uruguay
The Purkinje-cell swelling and vacuolation with subsequent cerebellar degeneration are suggestive of Purkinja-cell specific toxin that produces abnormal lysosome function and cell specific axonal transport. Expand
Poisonous plants affecting cattle in central-western Brazil
Poisonous plants affecting cattle in the Brazilian Central-Western region are reviewed and Brachiaria spp. Expand
Calbindin D28k Expression and the Absence of Apoptosis in the Cerebellum of Solanum bonariense L–Intoxicated Bovines
The findings suggest that S bonariense poisoning induces progressive Purkinje cell death that is not mediated by excitotoxicity or apoptotic activation, and suggests that excessive calcium excitatory stimulation does not induce rapid neuronal degeneration and death. Expand
A novel pathogenic mechanism for cerebellar lesions produced by Solanum bonariense in cattle
It is proposed that neuronal cytoskeletal alterations with subsequent interference of the axonal transport in Purkinje cells may play a relevant role in the pathogenesis of this neurodegenerative disorder, and also that demyelination and axonal loss in the cerebellar white matter, as well as astrogliosis in the gray matter, likely occur secondarily to Purkinja cell degeneration and death. Expand
Clinical and pathological aspects and cerebellar lectin binding in cattle poisoned with Solanum fastigiatum var. fastigiatum and Solanum bonariense.
Results of this study showed that in spontaneous poisoning by S. fastigiatum and S. bonariense in cattle, the pattern of lectin binding is similar to those observed in S.fastigiatu experimental conditions, suggesting a similar pathogenesis. Expand