• Publications
  • Influence
MicroRNAs Genomics, Biogenesis, Mechanism, and Function
  • D. Bartel
  • Medicine, Biology
  • Cell
  • 23 January 2004
TLDR
Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes. Expand
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
TLDR
In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set. Expand
MicroRNAs: Target Recognition and Regulatory Functions
  • D. Bartel
  • Medicine, Biology
  • Cell
  • 23 January 2009
TLDR
The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed. Expand
MicroRNA targeting specificity in mammals: determinants beyond seed pairing.
TLDR
Five general features of site context that boost site efficacy are uncovered: AU-rich nucleotide composition near the site, proximity to sites for coexpressed miRNAs (which leads to cooperative action), proximity to residues pairing to miRNA nucleotides 13-16, positioning within the 3'UTR at least 15 nt from the stop codon, and positioning away from the center of long UTRs. Expand
Most mammalian mRNAs are conserved targets of microRNAs.
TLDR
This work overhauled its tool for finding preferential conservation of sequence motifs and applied it to the analysis of human 3'UTRs, increasing by nearly threefold the detected number of preferentially conserved miRNA target sites. Expand
Predicting effective microRNA target sites in mammalian mRNAs
TLDR
It is shown that recently reported non-canonical sites do not mediate repression despite binding the miRNA, which indicates that the vast majority of functional sites are canonical. Expand
Prediction of Mammalian MicroRNA Targets
TLDR
The predicted regulatory targets of mammalian miRNAs were enriched for genes involved in transcriptional regulation but also encompassed an unexpectedly broad range of other functions. Expand
Computational identification of plant microRNAs and their targets, including a stress-induced miRNA.
TLDR
Comparative genomic approaches were developed to systematically identify both miRNAs and their targets that are conserved in Arabidopsis thaliana and rice, and the expression of miR395, the sulfurylase-targeting miRNA, increases upon sulfate starvation, showing that miRNAAs can be induced by environmental stress. Expand
MicroRNAS and their regulatory roles in plants.
TLDR
The importance of miRNA-directed gene regulation during plant development is now particularly clear and typically at the cores of gene regulatory networks, targeting genes that are themselves regulators, such as those encoding transcription factors and F-box proteins. Expand
Prediction of Plant MicroRNA Targets
TLDR
This work predicts regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity and identifies members of transcription factor gene families involved in developmental patterning or cell differentiation. Expand
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