• Publications
  • Influence
MicroRNAs Genomics, Biogenesis, Mechanism, and Function
  • D. Bartel
  • Biology, Medicine
  • Cell
  • 23 January 2004
MicroRNAs (miRNAs) are endogenous approximately 22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although theyExpand
  • 27,962
  • 1146
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with conserved complementarity to the seed (nucleotides 2-7) of the miRNA. An overrepresentation of conservedExpand
  • 10,503
  • 667
MicroRNAs: Target Recognition and Regulatory Functions
  • D. Bartel
  • Biology, Medicine
  • Cell
  • 23 January 2009
MicroRNAs (miRNAs) are endogenous approximately 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct theirExpand
  • 14,078
  • 538
MicroRNA targeting specificity in mammals: determinants beyond seed pairing.
Mammalian microRNAs (miRNAs) pair to 3'UTRs of mRNAs to direct their posttranscriptional repression. Important for target recognition are approximately 7 nt sites that match the seed region of theExpand
  • 3,428
  • 303
Most mammalian mRNAs are conserved targets of microRNAs.
MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-transcriptional repression. Many sites that match the miRNA seed (nucleotides 2-7), particularly those in 3'Expand
  • 6,295
  • 290
Prediction of Mammalian MicroRNA Targets
MicroRNAs (miRNAs) can play important gene regulatory roles in nematodes, insects, and plants by basepairing to mRNAs to specify posttranscriptional repression of these messages. However, the mRNAsExpand
  • 4,684
  • 256
Predicting effective microRNA target sites in mammalian mRNAs
MicroRNA targets are often recognized through pairing between the miRNA seed region and complementary sites within target mRNAs, but not all of these canonical sites are equally effective, and bothExpand
  • 2,611
  • 246
Computational identification of plant microRNAs and their targets, including a stress-induced miRNA.
MicroRNAs (miRNAs) are approximately 21-nucleotide RNAs, some of which have been shown to play important gene-regulatory roles during plant development. We developed comparative genomic approaches toExpand
  • 1,943
  • 186
MicroRNAS and their regulatory roles in plants.
MicroRNAs (miRNAs) are small, endogenous RNAs that regulate gene expression in plants and animals. In plants, these approximately 21-nucleotide RNAs are processed from stem-loop regions of longExpand
  • 2,166
  • 171
Prediction of Plant MicroRNA Targets
We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49Expand
  • 1,994
  • 169