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CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory
CD4+ and CD8+ peripheral blood T lymphocytes show mutually exclusive expression of CD45RA or CD45R0, two isoforms of the common leukocyte antigen that seem to recognize so-called virgin/unprimed andExpand
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Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets.
We have studied the effects of a life-long antigen stimulation on the clonal heterogeneity of human peripheral T cell subsets, as defined by their CD45 isoform expression. CD4+ or CD8+ T cells wereExpand
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The highly reducing sugar 2-deoxy-D-ribose induces apoptosis in human fibroblasts by reduced glutathione depletion and cytoskeletal disruption.
2-deoxy-D-Ribose (dRib), the most reducing sugar, induces apoptosis in normal human fibroblasts, as judged by cytoplasmic shrinkage, chromatin condensation, DNA fragmentation and mitochondrialExpand
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Different pathways of apoptosis revealed by 2‐chloro‐adenosine and deoxy‐D‐ribose in mammalian astroglial cells
Both the adenosine analogue 2‐chloro‐adenosine (2‐CA) and the reducing sugar deoxy‐D‐ribose (dRib) induce apoptosis of astroglial cells in rat brain primary cultures (Abbracchio et al.: BiochemExpand
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Apoptosis induced by 2‐chloro‐adenosine and 2‐chloro‐2′‐deoxy‐adenosine in a human astrocytoma cell line: Differential mechanisms and possible clinical relevance
We have previously demonstrated that 2‐chloro‐adenosine (2‐CA) can induce apoptosis of rat astroglial cells (Abbracchio et al. [1995] Biochem. Biophys. Res. Commun. 213:908–915). In the presentExpand
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Mitochondrial modifications during rat thymocyte apoptosis: a study at the single cell level.
Apoptosis is an active type of cell death, occurring under several physiological and pathological conditions. The role of cellular organelles such as mitochondria in this process is still an openExpand
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D-ribose and deoxy-D-ribose induce apoptosis in human quiescent peripheral blood mononuclear cells.
In previous papers we reported that D(-)-ribose and 2-deoxy-D-ribose, which rank at the top among reducing sugars, kill a variety of human and animal cells and cell lines. Here we demonstrate thatExpand
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Transcription factors DNA-binding activity in rat thymocytes undergoing apoptosis after heat-shock or dexamethasone treatment.
The onset of apoptosis is generally thought to require the induction of a novel genetic program. Accordingly, we studied the kinetic of DNA-binding activity of several transcription factors in ratExpand
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A novel action for adenosine: apoptosis of astroglial cells in rat brain primary cultures.
2-chloro-adenosine induced apoptosis of astroglial cells in rat brain cultures, as shown by flow cytometry and morphological analysis. The adenosine analogue was far more potent than severalExpand
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Activation of the A3 adenosine receptor affects cell cycle progression and cell growth
Abstract. The A3 adenosine receptor has been implicated in modulation of cell growth. As a first step to the characterization of the underlying mechanisms, we exposed Chinese hamster ovary (CHO)Expand
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