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Calcium plus vitamin D supplementation and the risk of fractures.
TLDR
Among healthy postmenopausal women, calcium with vitamin D supplementation resulted in a small but significant improvement in hip bone density, did not significantly reduce hip fracture, and increased the risk of kidney stones.
Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause.
TLDR
Whether the effects of hormone therapy on risk of cardiovascular disease vary by age or years since menopause began is explored to explore and women who initiated hormone therapy closer toMenopause tended to have reduced CHD risk compared with the increase inCHD risk among women more distant from menopausal symptoms.
Combined postmenopausal hormone therapy and cardiovascular disease: toward resolving the discrepancy between observational studies and the Women's Health Initiative clinical trial.
TLDR
Hazard ratio estimates for coronary heart disease, stroke, and venous thromboembolism in the observational study were 39-48% lower than those in the clinical trial following age adjustment, although there was evidence of some remaining difference for stroke.
Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: the Women's Health Initiative randomized trial.
TLDR
This randomized trial suggests that continuous combined estrogen plus progestin therapy may increase the risk of ovarian cancer while producing endometrial cancer rates similar to placebo, and provides additional support for caution in the use of continuous combined hormones.
Effect of dehydroepiandrosterone on oocyte and embryo yields, embryo grade and cell number in IVF.
TLDR
This study confirms the previously reported beneficial effects of DHEA supplementation on ovarian function in women with diminished ovarian reserve, andaired analysis of IVF cycle outcomes in 25 patients demonstrated significant increases in fertilized oocytes, normal day 3 embryos, embryos transferred and average embryo scores per oocyte after DHEa treatment.
Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function
TLDR
DHEA treatment resulted in significantly higher cumulative pregnancy rates and these data support a beneficial effect of DHEA supplementation among women with diminished ovarian function.
Habitual tea consumption and risk of osteoporosis: a prospective study in the women's health initiative observational cohort.
TLDR
The results from this study indicate that the effect of habitual tea drinking on bone density is small and does not significantly alter the risk of fractures among the US postmenopausal population.
Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks.
TLDR
BRCA1 mutations are associated with occult primary ovarian insufficiency, which may, at least in part, explain the link between infertility and breast/ovarian cancer risks.
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