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The Role of Cyclooxygenase-2 in Mediating the Effects of Histamine on Cell Proliferation and Vascular Endothelial Growth Factor Production in Colorectal Cancer
Purpose: Activity of histidine decarboxylase, the key enzyme in the synthesis of histamine, has been shown to be increased in several types of human tumors. We attempted to establish whether theExpand
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Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart.
Myocardial injury caused by ischemia and reperfusion comes from multiple pathogenic events, including endothelial damage, neutrophil extravasation into tissue, platelet and mast cell activation, andExpand
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Oxidative Stress by Monoamine Oxidase Mediates Receptor-Independent Cardiomyocyte Apoptosis by Serotonin and Postischemic Myocardial Injury
Background— Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A). Because hydrogenExpand
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Relaxin‐induced increased coronary flow through stimulation of nitric oxide production
1 Relaxin (RLX) is a multifunctional hormone which, besides its role in pregnancy and parturition, has also been shown to influence the cardiovascular system. In this study, we investigated theExpand
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Characterization of human adult stem‐cell populations isolated from visceral and subcutaneous adipose tissue
Adipose tissue is a dynamic endocrine organ with a central role in metabolism regulation. Functional differences in adipose tissue seem associated with the regional distribution of fat depots, inExpand
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Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling
The hormone relaxin (RLX) is produced by the heart and has beneficial actions on the cardiovascular system. We previously demonstrated that RLX stimulates mouse neonatal cardiomyocyte growth,Expand
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Relaxin activates the L-arginine-nitric oxide pathway in vascular smooth muscle cells in culture.
The peptide hormone relaxin (RLX) has been shown to elicit a powerful vasodilatory response in several target organs. This response is mediated by the stimulation of intrinsic nitric oxide (NO)Expand
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Notch Activation Differentially Regulates Renal Progenitors Proliferation and Differentiation Toward the Podocyte Lineage in Glomerular Disorders
Glomerular diseases account for 90% of end‐stage kidney disease. Podocyte loss is a common determining factor for the progression toward glomerulosclerosis. Mature podocytes cannot proliferate, butExpand
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Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury
Although recent preclinical and clinical studies have demonstrated that recombinant human relaxin (rhRLX) may have important therapeutic potential in acute heart failure and chronic kidney diseases,Expand
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Relaxin receptors and nitric oxide synthases: search for the missing link
  • S. Nistri, D. Bani
  • Medicine, Biology
  • Reproductive biology and endocrinology : RB&E
  • 5 February 2003
Researchers involved in the study of relaxin have welcomed the article by Hsu et al. [1], who eventually identified the receptors for this hormone. In the past, using labeled relaxin, specificExpand
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