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Approximate Bayesian computation in population genetics.
We propose a new method for approximate Bayesian statistical inference on the basis of summary statistics. The method is suited to complex problems that arise in population genetics, extending ideas… Expand
A genome-wide association study identifies novel risk loci for type 2 diabetes
Type 2 diabetes mellitus results from the interaction of environmental factors with a combination of genetic variants, most of which were hitherto unknown. A systematic search for these variants was… Expand
Inferring population history with DIY ABC: a user-friendly approach to approximate Bayesian computation
We propose here a computer program (DIY ABC) for inference based on approximate Bayesian computation (ABC), in which scenarios can be customized by the user to fit many complex situations involving any number of populations and samples. Expand
Identifying adaptive genetic divergence among populations from genome scans
The identification of signatures of natural selection in genomic surveys has become an area of intense research, stimulated by the increasing ease with which genetic markers can be typed. Loci… Expand
A tutorial on statistical methods for population association studies
- D. Balding
- Biology, Medicine
- Nature Reviews Genetics
- 1 October 2006
Although genetic association studies have been with us for many years, even for the simplest analyses there is little consensus on the most appropriate statistical procedures. Here I give an overview… Expand
Improved heritability estimation from genome-wide SNPs.
- D. Speed, G. Hemani, M. Johnson, D. Balding
- Biology, Medicine
- American journal of human genetics
- 7 December 2012
Estimation of narrow-sense heritability, h(2), from genome-wide SNPs genotyped in unrelated individuals has recently attracted interest and offers several advantages over traditional pedigree-based… Expand
Inferring coalescence times from DNA sequence data.
The paper is concerned with methods for the estimation of the coalescence time (time since the most recent common ancestor) of a sample of intraspecies DNA sequences. The methods take advantage of… Expand
Epigenome-wide association studies for common human diseases
Despite the success of genome-wide association studies (GWASs) in identifying loci associated with common diseases, a substantial proportion of the causality remains unexplained. Recent advances in… Expand
Population Structure and Cryptic Relatedness in Genetic Association Studies
We review the problem of confounding in genetic association studies, which arises principally because of population structure and cryptic relatedness. Many treatments of the problem consider only a… Expand
A method for quantifying differentiation between populations at multi-allelic loci and its implications for investigating identity and paternity
A method is proposed for allowing for the effects of population differentiation, and other factors, in forensic inference based on DNA profiles. Much current forensic practice ignores, for example,… Expand