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Energized mitochondria increase the dynamic range over which inositol 1,4,5‐trisphosphate activates store‐operated calcium influx
In eukaryotic cells, activation of cell surface receptors that couple to the phosphoinositide pathway evokes a biphasic increase in intracellular free Ca2+ concentration: an initial transient phaseExpand
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Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression
Stimulation of cells with physiological concentrations of calcium-mobilizing agonists often results in the generation of repetitive cytoplasmic Ca2+ oscillations. Although oscillations arise fromExpand
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Store‐operated Ca2+ entry depends on mitochondrial Ca2+ uptake
Store‐operated Ca2+ channels, which are activated by the emptying of intracellular Ca2+ stores, provide one major route for Ca2+ influx. Under physiological conditions of weak intracellular Ca2+Expand
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An examination of the secretion‐like coupling model for the activation of the Ca2+ release‐activated Ca2+ current ICRAC in RBL‐1 cells
1 One popular model for the activation of store‐operated Ca2+ influx is the secretion‐like coupling mechanism, in which peripheral endoplasmic reticulum moves to the plasma membrane upon storeExpand
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Dynamic Assembly of a Membrane Signaling Complex Enables Selective Activation of NFAT by Orai1
Summary NFAT-dependent gene expression is essential for the development and function of the nervous, immune, and cardiovascular systems and kidney, bone, and skeletal muscle [1]. Most NFAT proteinExpand
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Monovalent cation permeability and Ca2+ block of the store-operated Ca2+ current ICRAC in rat basophilic leukemia cells
Abstract. Like voltage-operated Ca2+ channels, store-operated CRAC channels become permeable to monovalent cations in the absence of external divalent cations. Using the whole-cell patch-clampExpand
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Mitofusin 2 Regulates STIM1 Migration from the Ca2+ Store to the Plasma Membrane in Cells with Depolarized Mitochondria*
Store-operated Ca2+ channels in the plasma membrane (PM) are activated by the depletion of Ca2+ from the endoplasmic reticulum (ER) and constitute a widespread and highly conserved Ca2+ influxExpand
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Permeation through store-operated CRAC channels in divalent-free solution: potential problems and implications for putative CRAC channel genes.
CRAC channels are key calcium conduits in both physiological and pathological states. Understanding how these channels are controlled is important as this will not only provide insight into a novelExpand
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Key Role for Store-Operated Ca2+ Channels in Activating Gene Expression in Human Airway Bronchial Epithelial Cells
Ca2+ entry into airway epithelia is important for activation of the NFAT family of transcription factors and expression of genes including epidermal growth factor that help orchestrate localExpand
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