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Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans
Automated comparison and clustering of the obtained in vivo expression patterns show that genes coexpressed in space and time tend to belong to common functional categories, enabling prediction of anatomical and temporal interaction territories between protein partners.
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
It is demonstrated that BBS-7 and Bbs-8 are required for the normal localization/motility of the IFT proteins OSM-5/Polaris andCHE-11, and to a notably lesser extent, CHE-2.
Molecular and Functional Characterization of a Family of Rat Brain T-type Calcium Channels*
Simulation of α1G, α1H, and α1I T-type channels in a thalamic neuron model cell produced unique firing patterns typical of different brain nuclei and suggests that the three channel types make distinct contributions to neuronal physiology.
The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes
ABC transporter evolution fits a pattern expected from a process termed 'dynamic-coherence', which may result from the broad substrate specificity of some ABC proteins, which both reduces selection against gene loss and leads to the facile sorting of functions among paralogs following gene duplication.
LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans
The characterization of the gene let-413 is reported which has a critical role in assembling adherens junctions in Caenorhabditis elegans and it is suggested that LET-413 acts as an adaptor protein involved in polarizing protein trafficking in epithelial cells.
High-Throughput In Vivo Analysis of Gene Expression in Caenorhabditis elegans
Using DNA sequences 5′ to open reading frames, we have constructed green fluorescent protein (GFP) fusions and generated spatial and temporal tissue expression profiles for 1,886 specific genes in
Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome
Analysis of the Caenorhabditis elegans ARL6 homolog indicates that it is specifically expressed in ciliated cells, and that, in addition to the postulated cytoplasmic functions of ARL proteins, it undergoes intraflagellar transport.
Changes in gene expression associated with developmental arrest and longevity in Caenorhabditis elegans.
Abundant antisense mitochondrial transcripts (2% of all tags), suggest the existence of an antisense-mediated regulatory mechanism in C. elegans mitochondria.