• Publications
  • Influence
Mechanisms of tinnitus.
  • D. Baguley
  • Medicine
    British medical bulletin
  • 1 October 2002
TLDR
Possible mechanisms for tinnitus within the auditory brain are reviewed, including important work on synchronised spontaneous activity in the cochlear nerve, and the concept of discordant damage between inner and outer hair cells is described.
Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss
TLDR
It is shown here that ATP6V0A4 is expressed within the human inner ear for the first time, providing further evidence for genetic heterogeneity in rdRTA, extend the spectrum of disease causing mutations in ATP 6V1B1 and ATP6v 0A4, and show ATP6 V0A 4 expression within the cochlea for thefirst time.
Pitch Comparisons between Electrical Stimulation of a Cochlear Implant and Acoustic Stimuli Presented to a Normal-hearing Contralateral Ear
TLDR
Four cochlear implant users, having normal hearing in the unimplanted ear, compared the pitches of electrical and acoustic stimuli presented to the two ears, and it was shown that substantial range effects occur with other widely used experimental methods, even for normal-hearing listeners.
Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans.
TLDR
Mutation of SECISBP2 is associated with a multisystem disorder with defective biosynthesis of many selenoproteins, highlighting their role in diverse biological processes.
Guidelines for the grading of tinnitus severity: the results of a working group commissioned by the British Association of Otolaryngologists, Head and Neck Surgeons, 1999.
TLDR
A five-point severity grading scheme is proposed and the entry criteria detailed and the five severity points are: slight, mild, moderate, severe and catastrophic.
Cochlear implants and tinnitus.
Tinnitus and cochlear implantation
TLDR
This review considers tinnitus experiences in patients undergoing cochlear implantation, this being of interest because the prevalence of tinnitis in this patient group prior to surgery may shed some light on the link between co chlear dysfunction and tinn Titus.
Tinnitus: A Multidisciplinary Approach
TLDR
A broad account of tinnitus and hyperacusis, detailing the latest research and developments in clinical management, incorporating insights from audiology, otology, psychology, psychiatry and auditory neuroscience is provided.
COL2A1 exon 2 mutations: relevance to the Stickler and Wagner syndromes
TLDR
Type 1 Stickler syndrome is caused by mutations in the gene encoding type II collagen (COL2A1), consistent with the major form of type II procollagen in non-ocular tissues having exon 2 spliced out, and counselling patients are all at high risk of retinal detachment.
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