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Brain-derived Neurotrophic Factor Regulates the Expression and Synaptic Delivery ofα-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits in Hippocampal Neurons*
TLDR
It is shown that BDNF acutely up-regulates the protein levels of AMPA receptor subunits in hippocampal neurons and induces the delivery ofAMPA receptors to the synapse.
Local Control of AMPA Receptor Trafficking at the Postsynaptic Terminal by a Small GTPase of the Rab Family*
TLDR
A new role for the cellular secretory machinery in the control of synaptic function and plasticity directly at the postsynaptic membrane is demonstrated, and Rab8 specifically drives the local delivery of AMPARs into synapses.
Motor protein–dependent transport of AMPA receptors into spines during long-term potentiation
TLDR
It is found that myosin Va associates with AMPARs through its cargo binding domain, and this interaction was enhanced by active, GTP-bound Rab11, which is also transported by the motor protein.
Targeting WEE1 Kinase in Cancer.
Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane
TLDR
A molecular and anatomical model is proposed that dissects AMPA receptor sorting and synaptic delivery within the spine, and uncovers new functions of the exocyst at the postsynaptic membrane.
Strategies and Approaches of Targeting STAT3 for Cancer Treatment.
TLDR
This review summarizes the development of STAT3 inhibitors organized by the approach used to inhibit STAT3, the current inhibitors of each class, and the assay systems used to evaluate STAT3 inhibition and offers an insight into future approaches for small molecule STAT3 inhibitor development.
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